RESEARCH PAPER

Tobacco specific nitrosamines and potential reduced exposure products for smokers: a preliminary evaluation of Advance^TM

A B Breland¹, M C Acosta², T Eissenberg³

¹ Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
² Departments of Psychiatry and Psychology, Virginia Commonwealth University
³ Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University

Correspondence to:
Correspondence to:
Thomas Eissenberg, PhD, Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Box 980205, Richmond, VA 23298-0205, USA;
teissenb{at}vcu.edu

Objective: To develop a method for evaluating the carcinogen delivery of potential reduced exposure products (PREPs) like Advance^TM, a PREP marketed to reduce smokers’ exposure to one tobacco specific nitrosamine (TSN), NNK, a potent lung carcinogen.

Design, setting, and participants: Latin square ordered, three condition, outpatient, crossover design with 12 smokers of light or ultra-light cigarettes (15 or more cigarettes/day). In each five day condition, participants either smoked own brand, Advance^TM, or no cigarettes. Also, on the first and last day of each condition, participants smoked one cigarette in the laboratory.

Main outcome measures: Subject rated measures of tobacco/nicotine withdrawal, expired air carbon monoxide, urine concentrations of cotinine and NNAL (one TSN biomarker), puff volume, duration, number, and interpuff interval.

Results: Relative to own brand, Advance^TM produced similar withdrawal suppression, slightly lower carbon monoxide, equivalent cotinine, and 51% lower NNAL concentrations. The lowest cotinine and NNAL concentrations were observed in the no cigarette condition. Participants took fewer puffs when smoking Advance^TM.

Conclusions: Past experience with PREPs that failed to reduce smoking’s harm demonstrates the need for clinical methods in PREP evaluation. This study shows how assessing PREP induced changes in withdrawal and exposure to carbon monoxide, nicotine, and carcinogens may help predict PREP harm reduction potential. Adequate withdrawal suppression, slightly lower concentrations of carbon monoxide, and reduction of one TSN biomarker were observed for Advance^TM. In the future, clinical methods like those described here may be valuable for evaluating PREPs before they are marketed publicly.

Keywords: carbon monoxide; carcinogen biomarkers; cotinine; nitrosamines; withdrawal

Abbreviations: FTC, Federal Trade Commission; IPI, interpuff interval; NNAL, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; PREP, potential reduced exposure product; TSN, tobacco specific nitrosamine; QSU, questionnaire of smoking urges, VAS, visual analogue scale

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Zeller, M., Hatsukami, D., and the Strategic Dialogue on Tobacco Harm Reducti, (2009). The Strategic Dialogue on Tobacco Harm Reduction: a vision and blueprint for action in the US. Tobacco Control 18: 324-332 [Abstract] [Full Text]  
• Rees, V. W., Wayne, G. F., Connolly, G. N. (2008). Puffing Style and Human Exposure Minimally Altered by Switching to a Carbon-Filtered Cigarette. Cancer Epidemiol. Biomarkers Prev. 17: 2995-3003 [Abstract] [Full Text]  
• Eissenberg, T (2006). The time for tobacco industry sponsored PREP evaluation has arrived. Tobacco Control 15: 1-2 [Full Text]  
• Hatsukami, D. K., Lemmonds, C., Zhang, Y., Murphy, S. E., Le, C., Carmella, S. G., Hecht, S. S. (2004). Evaluation of Carcinogen Exposure in People Who Used "Reduced Exposure" Tobacco Products. JNCI J Natl Cancer Inst 96: 844-852 [Abstract] [Full Text]