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The case of the disappearing nitrosamines: a potentially global phenomenon

Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy

Correspondence to:
N Gray
Division of Epidemiology and Biostatistics, European Institute of Oncology, via Ripamonti 435, 20141 Milan, Italy; nigel{at}uicc.ch

The cigarette usually carries in its smoke significant doses of carcinogenic tobacco specific nitrosamines (TSNAs), which have been implicated as causes of oral, lung, oesophageal, and pancreatic cancer. However, there is substantial variation in nitrosamine content of the smoke of modern cigarettes. This variation is both unacceptable and unnecessary, as TSNAs can be readily removed during the manufacturing process. Removing a known carcinogen needs no justification, even though proof of benefit may not be forthcoming for decades.

Keywords: tobacco specific nitrosamines; TSNA

Abbreviations: ISO, International Standard Organisation; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; TSNAs, tobacco specific nitrosamines

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