Tobacco Control

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
[Advanced]

Tobacco Control 2006;15:199-204; doi:10.1136/tc.2005.014118
Copyright © 2006 by the BMJ Publishing Group Ltd.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Karp, I
Right arrow Articles by Paradis, G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Karp, I
Right arrow Articles by Paradis, G

RESEARCH PAPER

Risk factors for tobacco dependence in adolescent smokers

I Karp1,*, J O’Loughlin1,{dagger}, J Hanley1, R F Tyndale2, G Paradis1,{dagger},{dagger}

1 Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Montréal, Québec, Canada
2 Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada

Correspondence to:
Dr Jennifer O’Loughlin
Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, Quebec H3A 1A2, Canada; jennifer.oloughlin{at}mcgill.ca

Objective: To study the incidence of conversion to tobacco dependence (TD) and the prevalence of the TD state in relation to several potential determinants in a sample of adolescent smokers.

Methods: Questionnaires were administered every 3–4 months to document TD symptoms, amount of cigarette consumption, and depression symptoms in a prospective cohort of 1293 grade 7 students in a convenience sample of 10 schools.

Results: Over 54 months of follow-up, 113 of 344 novice smokers converted to TD. The referent series for the analysis of incidence comprised 823 person-surveys. The prevalence series included 1673 person-surveys, contributed by 429 smokers. Conversion to TD and TD status were associated with the intensity of recent (that is, past 3-month) cigarette consumption (adjusted incidence rate ratio (aIRR) 1.63 (95% confidence interval (CI) 1.36 to 1.97) and adjusted prevalence odds ratio (aPOR) 1.35 (95% CI 1.23 to 2.48) per 100 cigarettes per month), slowest CYP2A6 activity (aIRR 4.19 (95% CI 1.38 to 12.76) and aPOR 2.30 (95% CI 1.29 to 4.09)), depression score (aIRR 1.61 (95% CI 1.17 to 2.21) and aPOR 1.47 (95% CI 1.22, 1.75) per 1-unit change). Additional determinants included, for conversion to TD, time since onset of cigarette use (aIRR 0.76 (95% CI 0.58 to 1.00) per year) and, for the TD state, positive TD status six months ago (aPOR 3.53 (95% CI 2.41 to 5.19)).

Conclusions: TD risk in adolescents is associated with intensity of recent cigarette consumption, while the role of more distant cigarette consumption appears small; subjects with slow nicotine metabolism and those with more depression symptoms are at increased risk of becoming tobacco dependent. The risk of being tobacco dependent is considerably higher in subjects who had previously developed the TD state.


Abbreviations: aIRR, adjusted incidence rate ratio; aPOR, adjusted prevalence odds ratio; CI, confidence interval; GEE, generalised estimating equation; OR, odds ratio; NDIT, Natural History of Nicotine Dependence Study; SE, standard error; TD, tobacco dependence

Keywords: tobacco dependence; tobacco use disorder; smoking; risk factors; adolescent




This article has been cited by other articles:


Home page
Arch Pediatr Adolesc MedHome page
T. A. Barnett, L. Gauvin, M. Lambert, J. O'Loughlin, G. Paradis, and J. J. McGrath
The Influence of School Smoking Policies on Student Tobacco Use
Arch Pediatr Adolesc Med, September 1, 2007; 161(9): 842 - 848.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
J. Audrain-McGovern, N. A. Koudsi, D. Rodriguez, E. P. Wileyto, P. G. Shields, and R. F. Tyndale
The Role of CYP2A6 in the Emergence of Nicotine Dependence in Adolescents
Pediatrics, January 1, 2007; 119(1): e264 - e274.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2006 by the BMJ Publishing Group Ltd.