Tobacco Control

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Tobacco Control 2006;15:77
Copyright © 2006 by the BMJ Publishing Group Ltd.

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ECHO

Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation

J C Khan, D A Thurlby, H Shahid, D G Clayton, J R W Yates, M Bradley, A T Moore, A C Bird for the Genetic Factors in AMD Study

The first 150 words of the full text of this article appear below.


Background/aims:
There is evidence that smoking is a risk factor for age related macular degeneration (AMD). However, not all studies have demonstrated this association and several key questions about the role of smoking in AMD have still to be determined. The aim of this study was to further investigate this relation for both choroidal neovascularisation (CNV) and geographic atrophy (GA).


Methods:
To investigate the relation between smoking and the risk of developing age related macular degeneration (AMD) in white people, 435 cases with end stage AMD were compared with 280 controls. All subjects had graded stereoscopic colour fundus photography and AMD was defined as the presence of GA or CNV. Smoking history was assessed using multiple parameters in a detailed questionnaire.


Results:
Comparison of current and former smokers with non-smokers was consistent with smoking being a risk factor for AMD but did not reach statistical significance. There was a strong association between AMD . . . [Full text of this article]







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Copyright © 2006 by the BMJ Publishing Group Ltd.