Editor,—It has been known for more than 150 years that nicotine is the chemical in tobacco that is responsible for the perceived salutary as well as the adverse effects among users. Efforts to market “denicotinised” tobacco have repeatedly failed. The 1964 report of the advisory committee to the US Surgeon General stated, “Denicotinized tobacco has not found general public acceptance as a substitute.”1 Recently, Philip Morris Companies withdrew “Next”, their low nicotine cigarette brand, because of poor sales. However, Liggett Group …