21 day versus 90 day inhalation studies
| Project number | TPM μg/l | Nasal reserve cell hyperplasia | Total vocal cord hyperplasia | Total vocal cord metaplasia |
|---|---|---|---|---|
| 312569 (21 day) | Sham | − | − | − |
| SS 2 | − | − | − | |
| SS 6 | − | + | + | |
| 312770 (90 day) | Sham | − | − | − |
| SS 2 | + | + | − | |
| SS 6 | + | + | + |
21 day versus 90 day inhalation studies
| Project number | TPM μg/l | Nasal reserve cell hyperplasia | Total vocal cord hyperplasia | Total vocal cord metaplasia |
|---|---|---|---|---|
| 312569 (21 day) | Sham | − | − | − |
| SS 2 | − | − | − | |
| SS 6 | − | + | + | |
| 312770 (90 day) | Sham | − | − | − |
| SS 2 | + | + | − | |
| SS 6 | + | + | + |
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