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Does use of ‘non-trial’ cessation support help explain the lack of effect from offering NRT to quitline callers in a RCT?
  1. Graeme Docherty1,
  2. Sarah Lewis1,
  3. Andy McEwen2,
  4. Linda Bauld3,
  5. Tim Coleman4
  1. 1Department of Epidemiology and Public Health, UK Centre for Tobacco Control Studies, University of Nottingham, Nottingham, UK
  2. 2Department of Epidemiology and Public Health, Cancer Research UK Health Behaviour Research Centre, UK Centre for Tobacco Control Studies, University College London, London, UK
  3. 3UK Centre for Tobacco Control Studies, Institute of Social Marketing, University of Stirling, Stirling, UK
  4. 4Division of Primary Care, UK Centre for Tobacco Control Studies and NIHR School for Primary Care Research, University of Nottingham, Queen's Medical Centre, Nottingham, UK
  1. Correspondence to Graeme Docherty, Department of Epidemiology and Public Health, UK Centre for Tobacco Control Studies, University of Nottingham, C100, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK; graeme.docherty{at}nottingham.ac.uk

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Introduction

Quitlines help smokers to stop but few studies have explored how behavioural and medicinal interventions can be optimally delivered via this route.1 One of these was the PORTSSS trial, which found that offering free nicotine replacement therapy (NRT) vouchers did not increase cessation rates compared with no offer.2 It also found that a ‘proactive’, more intensive call regime from/to clients did not improve cessation rates over ‘usual care’. Was it possible that participants who did not receive a voucher for NRT sought out and used other forms of cessation support, which minimised any effect of receiving the NRT voucher? Use of ‘non-trial’ support varied across PORTSSS trial intervention groups and, in this analysis, we sought to determine whether or not use of this substantially affected trial findings.

Methods

Our secondary analysis included all 2591 randomised participants of the PORTSSS trial. PORTSSS was a randomised controlled trial (RCT) of an English, government-funded quitline, comparing two forms of behavioural support, with and without the offer of a free NRT voucher using a parallel-group, factorial 2×2 design. Non-trial support …

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