Summary
Subjects in the National Academy of Sciences-National Research Council Twin Registry of 31,848 male twin veterans were followed for mortality from 1 January 1946, or from the date of entry into military service if that was later, to 31 December 1978. During this time 3,573 deaths occurred among them, 837 due to trauma and 2,712 due to disease.
Mortality from all causes for the entire follow-up period was 10.2% among 11,350 monozygotic (MZ) twins and 11.4% among 14,450 dizygotic (DZ) twins. Mortality of veterans is known to be favorable compared to U.S. males. Among U.S. males of the same ages as the two respective twin zygosity groups, a mortality of 13.9% would have been expected during this time period. Observed mortality from trauma was 2.3% for MZ twins and 2.5% for DZ twins, with 3.0% expected in either group. Observed mortality from all disease was 7.9% for MZ twins and 8.8% for DZ twins, with 10.9% expected in either group.
For total mortality, the case twin concordance rates, based on individual deaths, were 28.2% among MZ twins and 17.7% among DZ twins. For trauma, respectively by zygosity, these concordance rates were 6.9% and 3.9%. In this sample, familial factors appear to be of little consequence in trauma deaths. For all disease the concordance rates were 30.1% and 17.4%. Estimating heritability of liability to death from disease, as proposed by Edwards (1969), provides values of h 2=r=0.51 for MZ twins, h 2=2r=0.48 for DZ twins, and h 2=2(r MZ−r DZ=0.54 using data for the two zygosity groups combined.
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References
Allen G (1979) Holzinger's HC revised. Acta Genet Med Gemellol 28: 161–164
Beebe GW, Simon AH (1969) Ascertainment of mortality in the US veteran population. Am J Epidemiol 89:636–643
Behrman JR, Hrubec Z, Taubman P, Wales TJ (1980) Socioeconomic success. A study of the effects of genetic endowments, family environment, and schooling. North-Holland Publishing Company, Amsterdam New York Oxford
Bulmer MG (1970) The biology of twinning in man. Clarendon Press, Oxford, pp 68–94
Cederlof R, Floderus B, Friberg L (1970) Cancer in MZ and DZ twins. Acta Genet Med Gemellol 19:69–74
Cederlof R, Friberg L, Jonsson E, Kaij L (1961) Studies on similarity diagnosis in twins with the aid of mailed questionnaires. Acta Genet 11:338–362
Cederlof R, Lorich U (1978) The Swedish twin registry. In: Nance WE (ed) Twin research, part B: Biology and epidemiology. Alan R Liss, Inc, New York, pp 189–195
Dublin LI, Lotka AF, Spiegelman M (1949) Length of life. The Ronald Press Company, New York
Edwards JH (1969) Familial predisposition in man. Br Med Bull 25: 58–64
Falconer DS (1965) The inheritance of liability to certain diseases estimated from the incidence among relatives. Ann Hum Genet 29: 51–76
Finch CE, Hayflick L (eds) (1977) Handbook of the biology of aging. Van Norstand Rheinhold Company, New York
Haldane JBS (1955–56) The estimation and significance of the logarithm of a ratio of frequencies. Ann Hum Genet 20:309–311
Harvald B, Hauge M (1965) Hereditary factors elucidated by twin studies. In: Neel JV, Shaw MW, Schull WJ (eds) Genetics and the epidemiology of chronic disease. PHS Publication No 1163, US Government Printing Office, Washington, DC, pp 61–76
Hauge M, Harvald B, Fischer M, Gotlieb-Jensen K, Juel-Nielsen N, Raebild I, Shapiro R, Videbech T (1968) The Danish twin register. Acta Genet Med Gemellol 17:315–332
Holm NV, Hauge M, Harvald B (1980) Etiologic factors of breast cancer elucidated by a study of unselected twins. J Natl Cancer Inst 65: 285–298
Hrubec Z, Allen G (1975) Methods and interpretation of twin concordance data (Letter to the editor). Am J Hum Genet 27:808–809
Hrubec Z, Neel JV (1978) The National Academy of Sciences-National Research Council Twin Registry: Ten years of operation. In: Nance WE (ed) Twin research, part B: Biology and epidemiology. Alan R Liss, Inc, New York, pp 153–172
Jablon S, Neel JV, Gershowitz H, Atkinson GF (1967) The NAS-NRC twin panel: Methods of construction of the panel, zygosity diagnosis, and proposed use. Am J Hum Genet 19:133–161
Jarvik LF, Falek A, Kallmann FJ, Lorge I (1960) Survival trends in a senescent twin population. Am J Hum Genet 12:170–179
Kaprio J, Sarna S, Koskenvuo M, Rantasalo I (1978) The Finnish twin registry: Formation and compilation, questionnaire study, zygosity determination procedures, and research program. In: Nance WE (ed) Twin research, part B: Biology and epidemiology. Alan R Liss, Inc, New York, pp 179–184
Kringlen E (1978) Norwegian twin registers. In: Nance WE (ed) Twin research, part B: Biology and epidemiology. Alan R Liss, Inc, New York, pp 185–187
Myers GC, Pitts AM (1977) Alternative projections of the US male veteran population 1970–2000. Working paper from Center for Demographic Studies, Duke University, July 1976, for report by National Research Council, Health care for American veterans. National Academy of Sciences, Washington, DC
Schneider EL (ed) (1978) The genetics of aging. Plenum Press, New York
Seltzer CC, Jablon S (1974) Effects of selection on mortality. Am J Epidemiol 100:367–372
Simms HS, Berg BN, Davies DF (1959) Onset of disease and the longevity of rat and man. In: Wolstenholme GEW, O'Connor M (eds) Ciba Foundation colloquia on ageing, vol 5: The lifespan of animals. Little, Brown and Company, Boston, pp 72–89
Smith C (1974) Concordance in twins: Methods and interpretation. Am J Hum Genet 26:454–466
Torgersen S (1979) The determination of twin zygosity by means of a mailed questionnaire. Acta Genet Med Gemellol 28:225–236
US Department of Health, Education, and Welfare (1968) Eighth revision international classification of diseases, adapted for use in the United States. PHS Publication No 1693, US Government Printing Office, Washington, DC
Vogel F, Motulsky AG (1979) Human genetics, Problems and approaches. Springer-Verlag, Berlin Heidelberg New York, pp 586–590
Wyshak G (1978) Fertility and longevity in twins, sibs, and parents of twins. Soc Biol 25:315–330
Wyshak G (1981) Personal communication, March 3, 1981
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Hrubec, Z., Neel, J.V. Familial factors in early deaths: Twins followed 30 years to ages 51–61 in 1978. Hum Genet 59, 39–46 (1981). https://doi.org/10.1007/BF00278852
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DOI: https://doi.org/10.1007/BF00278852