Cigarette smokers self-administer intravenous nicotine
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Cited by (135)
The incentive amplifying effects of nicotine: Roles in alcohol seeking and consumption
2022, Advances in PharmacologyCitation Excerpt :In this regard, preclinical animal models are widely employed given their utility in characterizing precise neurobiological processes, drug–drug interactions, and long-term changes that are involved across nicotine's various actions (Koob, Kenneth Lloyd, & Mason, 2009). Although smoked tobacco has been referred to as one of the most addictive and harmful drugs (Nutt, King, Saulsbury, & Blakemore, 2007), the evidence indicating that nicotine is reinforcing in the absence of tobacco smoke or other stimuli is scant and debated (Dar & Frenk, 2004; Henningfield & Goldberg, 1983; Henningfield, Miyasato, & Jasinski, 1983; Perkins, Grobe, Caggiula, Wilson, & Stiller, 1997) (Perkins, 2004; Perkins et al., 2017; Rose, Behm, Westman, Bates, & Salley, 2003; Rose & Corrigall, 1997). Notably, studies demonstrating intravenous nicotine self-administration in human smokers have required the presence of auditory, visual, or olfactory smoke cues coincident with nicotine infusion (Harvey et al., 2004; Rose, Behm, Westman, & Bates, 2003).
The effects of nicotine on conditioning, extinction, and reinstatement in humans
2018, Addictive BehaviorsCitation Excerpt :Therefore, it may be the case that non-dependent users (FTND = 0) are more sensitive to the aversive effects of nicotine via lozenge, accounting for their lack of CPP. As described previously, numerous studies emphasize the inherently rewarding nature of nicotine as evidenced by increased self-administration behavior (Henningfield et al., 1983; Le Foll & Goldberg, 2009) and by nicotine's ability to produce a CPP (Fudala, Teoh, & Iwamoto, 1985; Iwamoto, 1990; Le Foll & Goldberg, 2004). However, CPP results using nicotine have been equivocal.
Cognitive avoidance and aversive cues related to tobacco in male smokers
2017, Addictive BehaviorsCitation Excerpt :Tobacco use disorder is the most common substance use disorder worldwide and smoking is a leading cause of death (Jaffe, 1990; World Health Organization, 2008). Among the > 2000 compounds contained in cigarettes, nicotine is regarded as the only component associated with dependence, tolerance and reinforcement, which lead to addiction (Henningfield, Miyasato, & Jasinski, 1983; Stolerman & Jarvis, 1995). In 2013, almost 55.8 million Americans (21.3% of the population) were current cigarette smokers (National Institute on Drug Abuse, 2015) and, similarly, about 10 million Koreans (24.2% of the population) were current smokers in 2014 (Ministry of Health and Welfare and Korea Centers for Disease Control and Prevention, 2014).
Skin contamination as pathway for nicotine intoxication in vapers
2017, Toxicology in VitroOverview of Nicotine Withdrawal and Negative Reinforcement (Preclinical)
2017, Negative Affective States and Cognitive Impairments in Nicotine Dependence