Table 3

Coefficient of determination (r²) of plasma, breast milk, saliva, and urine concentrations of bupropion and metabolites

	Plasma bupro	Plasma hydroxy	Plasma erythro	Plasma threo	Breast milk bupro	Breast milk hydroxy	Breast milk erythro	Breast milk threo	Saliva bupro	Saliva hydroxy	Saliva erythro	Saliva threo
Numbers displayed are the coefficient of determination (p value). Bolding indicates associations that are significant (p<0.05).
Bupro, bupropion; erythro, erythrohydrobupropion; hydroxy, hydroxybupropion; threo, threohydrobupropion.
Plasma bupro	1.00
Plasma hydroxy	0.11	1.00
	(0.35)
Plasma erythro	0.10	0.89	1.00
	(0.39)	(<0.01)
Plasma threo	0.06	0.57	0.82	1.00
	(0.51)	(0.01)	(<0.01)
Breast milk bupro	0.03	0.01	0.01	0.08	1.00
	(0.65)	(0.79)	(0.85)	(0.43)
Breast milk hydroxy	0.15	0.88	0.82	0.66	0.08	1.00
	(0.27)	(<0.01)	(<0.01)	(<0.01)	(0.43)
Breast milk erythro	0.01	0.47	0.71	0.76	0.004	0.45	1.00
	(0.74)	(0.03)	(<0.01)	(<0.01)	(0.87)	(0.03)
Breast milk threo	0.04	0.16	0.40	0.73	0.06	0.22	0.78	1.00
	(0.57)	(0.25)	(0.05)	(<0.01)	(0.48)	(0.17)	(<0.01)
Saliva bupro	0.73	0.003	0.001	0.01	0.02	0.0001	0.12	0.13	1.00
	(<0.01)	(0.88)	(0.93)	(0.83)	(0.71)	(0.97)	(0.33)	(0.30)
Saliva hydroxy	0.53	0.04	0.03	0.0001	0.09	0.04	0.01	0.09	0.75	1.00
	(0.02)	(0.58)	(0.61)	(0.99)	(0.41)	(0.57)	(0.76)	(0.40)	(<0.01)
Saliva erythro	0.51	0.07	0.10	0.02	0.16	0.04	0.01	0.02	0.67	0.85	1.00
	(0.02)	(0.45)	(0.36)	(0.70)	(0.26)	(0.58)	(0.84)	(0.68)	(<0.01)	(<0.01)
Saliva threo	0.50	0.02	0.06	0.02	0.11	0.01	0.001	0.01	0.75	0.80	0.95	1.00
	(0.02)	(0.67)	(0.49)	(0.70)	(0.34)	(0.79)	(0.93)	(0.78)	(<0.01)	(<0.01)	(<0.01)
Urine bupro	0.05	0.002	0.03	0.01	0.77	0.01	0.08	0.04	0.002	0.04	0.12	0.11
	(0.54)	(0.90)	(0.61)	(0.77)	(<0.01)	(0.83)	(0.43)	(0.59)	(0.90)	(0.57)	(0.33)	(0.34)
Urine hydroxy	0.03	0.01	0.05	0.03	0.10	0.01	0.05	0.02	0.07	0.03	0.22	0.28
	(0.61)	(0.76)	(0.54)	(0.64)	(0.37)	(0.76)	(0.52)	(0.68)	(0.45)	(0.62)	(0.17)	(0.12)
Urine erythro	0.05	0.01	0.01	0.01	0.10	0.01	0.002	0.03	0.10	0.09	0.22	0.21
	(0.54)	(0.76)	(0.81)	(0.82)	(0.37)	(0.78)	(0.89)	(0.66)	(0.39)	(0.39)	(0.17)	(0.18)
Urine threo	0.06	0.04	0.01	0.04	0.20	0.002	0.001	0.13	0.10	0.16	0.27	0.20
	(0.48)	(0.58)	(0.79)	(0.59)	(0.20)	(0.92)	(0.92)	(0.30)	(0.38)	(0.25)	(0.12)	(0.19)