Project number | Smoke type μg/l TPM† | Mortality | % initial body weight | Rectal temperature °C‡ | Respiratory frequency‡ | Nasal reserve cell hyperplasia | Nasal squamous metaplasia | Nasal epithelial cornification | Atrophy olfactory epithelium | Necrosis nasal epithelium | Trachea reserve cell hyperplasia |
---|---|---|---|---|---|---|---|---|---|---|---|
−, not observed; +, observed; ±, observed in 10% or fewer of subjects; empty cell: no data. | |||||||||||
*½: indicates half day exposure (210 minutes instead of 420 minutes). | |||||||||||
†1 μg/l: 1000 μg/m3. | |||||||||||
‡Body temperature and respiratory frequency were measured at the end of the exposure. | |||||||||||
MS, mainstream smoke; SS, sidestream smoke. | |||||||||||
304714 | Sham | 0 | 150% | 37 | 107 | − | − | − | − | − | |
MS 170 | 1/20 (5%) | 130% | 36 | 91 | + | − | ± | ± | − | ||
SS 160 | 23/40 (57%) | 80% | 32 | 86 | + | + | + | + | + | ||
306120,22–24 | Sham | 0 | 137% | 36.7 | 113 | − | − | − | − | − | |
MS 371 | 17/20 (85%) | 97% | 29.6 | 98 | + | + | + | + | + | ||
MS 181 | 0 | 117% | 34.2 | 111 | − | + | + | − | + | ||
MS 86 | 0 | 127% | 36.8 | 123 | − | − | − | − | − | ||
SS 89 | 0 | 114% | 33.7 | 89 | + | + | + | + | + | ||
SS 89 ½* | 0 | 126% | 34.9 | 95 | + | + | + | + | + | ||
306925–29 | Sham | 0 | 140% | 37 | 107 | ||||||
MS 510 | 16/20 (80%) | 78% | 28.3 | 95 | |||||||
SS 119 | 2/24 (8%) | 89% | 32.7 | 74 | |||||||
SS 68 | 0 | 114% | 34.7 | 82 | |||||||
308130–33 | Sham | 0 | 130% | 36.3 | 137 | ||||||
MS 526 | 14/24 (58%) | 82% | 31.1 | 96 | |||||||
MS 261 | 0 | 116% | 35.9 | 110 | |||||||
SS 133 | 11/24 (46%) | 86% | 33.2 | 79 | |||||||
SS 59 | 0 | 116% | 36.0 | 97 | |||||||
311334 | Sham | 0 | 142% | − | − | − | − | − | − | ||
MS 60 | 0 | 134% | + | + | + | − | − | + | |||
SS 60 | 0 | 124% | + | + | + | + | − | + |