Results of sensitivity analysis (%)
| Toxicant | Original model | Model A | Model B | Model C | Model D | Model E |
|---|---|---|---|---|---|---|
| 1. Plasma nicotine | 34.0 | 26.9 | 18.1 | 24.5 | 20.6 | 42.3 |
| 2. Expired carbon monoxide | 73.5 | 66.4 | 54.3 | 63.6 | 58.2 | 79.8 |
| 3. Tobacco-specific nitrosamines | ||||||
| NNK | 32.6 | 25.7 | 17.2 | 23.4 | 23.4 | 40.8 |
| 4. Polycyclic aromatic hydrocarbons | ||||||
| Naphthalene | 35.3 | 28.1 | 19.0 | 25.6 | 21.6 | 43.8 |
| Fluorene (1-Fluor) | 24.0 | 18.4 | 11.9 | 16.6 | 13.7 | 31.0 |
| Fluorene (2-Fluor) | 27.6 | 21.4 | 14.0 | 19.4 | 16.1 | 35.2 |
| Fluorene (3-Fluor) | 20.4 | 15.5 | 9.9 | 13.9 | 11.5 | 26.8 |
| Phenanthrene | 52.1 | 43.8 | 31.8 | 40.7 | 35.4 | 60.8 |
| Pyrene | 56.9 | 48.5 | 36.1 | 45.4 | 39.9 | 65.3 |
| 5. Volatile organic chemicals | ||||||
| Ethylene oxide | 37.4 | 29.9 | 20.4 | 27.3 | 23.1 | 46.0 |
| Acrylonitrate | 17.2 | 12.9 | 8.2 | 11.5 | 9.4 | 22.8 |
| Acrolein | 41.7 | 33.8 | 23.5 | 31.1 | 26.5 | 50.5 |
| Propylene oxide | 39.1 | 31.5 | 21.6 | 28.8 | 24.5 | 47.8 |
| 1,3-Butadiene | 23.6 | 18.0 | 11.7 | 16.3 | 13.4 | 30.5 |
| Acrylamide | 45.0 | 36.9 | 26.0 | 34.0 | 29.2 | 53.9 |
| Benzene | 71.9 | 64.6 | 52.3 | 61.7 | 56.3 | 78.5 |
Model A decreased session duration to 50 min; model B decreased session duration to 30 min; model C decreased proportion of solo use by 20%; model D decreased proportion of solo use by 50%; model E increased the number of cigarette and waterpipe states to 35 and 2875, respectively. NNK, nicotine-derived nitrosamine ketone.