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Personality and the inheritance of smoking behavior: A genetic perspective

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Abstract

In contrast to the extensive research effort to understand the genetic contribution to alcoholism risk, there has been little research directed at understanding genetic influences on smoking behavior. Data from large twin studies in Scandinavia and Australia are consistent with a major genetic influence on the probability that an individual will become a smoker (“initiation”) and will persist in the smoking habit once smoking has started (“persistence”). We use data from the 1988/1989 follow-up survey of the Australian NH&MRC twin panel to determine to what degree personality measures (Tridimensional Personality Questionnaire, Eysenck Personality Questionnaire—Revised) and attitudinal and sociodemographic variables (social and political conservatism, education, religious involvement) might account for genetic or environmental influences on smoking. While we find significant phenotypic associations between these variables and smoking, these are too modest to account for much of the genetic variance. Possible mechanisms by which this genetic variance may arise are discussed.

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References

  • Allgulander, C., Nowak, J., and Rice, J. P. (1991). Psychopathology and treatment of 30,344 twins in Sweden. II. Heritability estimates of psychiatric diagnosis and treatment in 12,884 twin pairs.Acta Psychiatr. Scand. 83:12–15.

    Google Scholar 

  • Allgulander, C., Nowak, J., and Rice, J. P. (1992). Psychopathology and treatment of 30,344 twins in Sweden.Acta Psychiatr. Scand. 86:421–422.

    Google Scholar 

  • Baker, L. A., Treloar, S. A., Reynolds C., Heath, A. C., and Martin, N. G. (1994). Genetics of educational attainment in Australian twins: Sex differences and secular changes.Behav. Genet. (in press).

  • Begleiter, H. (1993). Collaborative study on the genetics of alcoholism. Symposium presented at the Research Society on Alcoholism meeting, San Antonio, TX, June 19–24.

  • Carmelli, D., Swan, G. E., Robinette, D., and Fabsitz, R. (199). Genetic influence on smoking—a study of male twins.N. Engl. J. Med. 327:881–883.

    Google Scholar 

  • Cederlof, R., Epstein, F. H., Friberg, L. T., Hrubec, Z., and Radford, E. P. (1971). Twin registries in the study of chronic diseases (with particular reference to the relation of smoking to cardiovascular and pulmonary diseases).Acta Med. Scand. Suppl. 523:1–40.

    Google Scholar 

  • Cloninger, C. R. (1987). Neurogenetic adaptive mechanisms in alcoholism.Science 236:410–416.

    Google Scholar 

  • Cloninger, C. R. (1990). Genetic epidemiology of alcoholism: Observations critical to the design and analysis of linkagenetics and Biology of Alcoholism, Banbury Report No. 32, Cold Spring Harbor Laboratory Press, Plainview, NY, pp. 105–129.

    Google Scholar 

  • Cloninger, C. R., Bohman, M., and Sigvardsson, S. (1981). Inheritance of alcohol abuse: Cross-fostering analysis of adopted men.Arch. Gen. Psychiat. 38:861–868.

    Google Scholar 

  • Cloninger, C. R., Reich, T., Sigvardsson, S., von Knorring, A. L., and Bohman, M. (1988). Effects of changes in alcohol use between generations on inheritance of alcohol abuse. In Rose, R. M., and Barrett, J. E. (eds.),Alcoholsim: Origins and Outcome, Raven Press, New York, pp. 49–74.

    Google Scholar 

  • Cloninger, C. R., Pryzbeck, T. R., and Svrakic, D. M. (1991). The tridimensional personality questionnaire: U.S. normative data.Psychol. Rep. 69:1047–1057.

    Google Scholar 

  • Collins, A. C., and Marks, M. J. (1989). Chronic nicotine exposure and brain nicotinic receptors—Influence of genetic factors. In Nordberg, A., Fuxe, K., Holmstedt, B., and Sundwall, A. (eds.),Progress in Brain Research, Vol. 79, pp. 137–146.

  • Crabbe, J. C., Belknap, J. K., and Buck, K. J. (1994). Genetic animal models of alcohol and drug abuse.Science 264: 1637–1816.

    Google Scholar 

  • Eaves, L. J., and Eysenck, H. J. (1980). The genetics of smoking. In Eysenck, H. J. (ed.),The Causes and Effects of Smoking, Maurice Temple Smith, London, pp. 140–314.

    Google Scholar 

  • Eaves, L. J., Eysenck, H. J., and Martin, N. G. (1989).Genes, Culture and Personality: An Empirical Approach, Academic Press, London.

    Google Scholar 

  • Eysenck, H. J. (1980).The Causes and Effects of Smoking, Maurice Temple Smith, London.

    Google Scholar 

  • Eysenck, S. B. G., Eysenck, H. J., and Barrett, P. (1985). A revised version of the psychoticism scale.Personal. Indiv. Diff. 6:21–29.

    Google Scholar 

  • Grunberg, N. E., Winders, S. E., and Wewers, M. E. (1991). Gender diferences in tobacco use.Health Psychol. 10: 143–153.

    Google Scholar 

  • Hannah, M. C., Hopper, J. L., and Mathews, J. D. (1985). Twin concordance for a binary trait. II. Nested analysis of eversmoking and ex-smoking traits and unnested analysis of a “committed-smoking” trait.Am. J. Hum. Genet. 37: 153–165.

    Google Scholar 

  • Health, A. C., and Madden, P. A. F. (1994). Genetic influences on smoking behavior. In Turner, J. R., Cardon, L. R. and Hewitt, J. K. (eds.),Behavior Genetic Applications in Behavioral Medicine Research, Plenum, New York.

    Google Scholar 

  • Heath, A. C., and Martin, N. G. (1993a) Genetic models for the natural history of smoking: Evidence for a genetic influence on smoking persistence.Addict. Behav. 18:19–34.

    Google Scholar 

  • Heath, A. C., and Martin, N. G. (1993b). Social and political conservatism as heritable dimensions of personality: A longitudinal perspective. Presented at Behavior Genetics Association 23rd Annual Meeting, Sydney, Australia, July 13–16.

  • Heath, A. C., Cates, R. C., Martin, N. G., Meyer, J., Hewitt, J. K., Neale, M. C., and Eaves, L. J. (1993). Genetic contribution to risk of smoking initiation: Comparisons across birth cohorts and across cultures.J. Substance Abuse 5:221–246.

    Google Scholar 

  • Heath, A. C., Cloninger, C. R., and Martin, N. G. (1994a). Testing a model for the genetic structure of personality: A comparison of the personality systems of Cloninger and Eysenck.J. Personal. Soc. Psychol. 66:762–775.

    Google Scholar 

  • Health, A. C., Madden, P. A. F., Cloninger, C. R., and Martin, N. G. (1994b). Genetic and environmental structure of personality. In Cloninger, C. R. (ed.),Personality and Psychopathology, American Psychiatric Press, Washington, DC (in press).

    Google Scholar 

  • Heath, A. C., Slutske, W. S., and Madden, P. A. F. (1994c). Gender differences in the genetic contribution to alcoholism risk and dirnking patterns. In Wilsnack, R. W., and Wilsnack, S. C. (eds.),Gender and Alcohol, Rutgers, New Brunswick, NJ (in press).

    Google Scholar 

  • Hrubec, Z., and Neel, J. V. (1978). The National Academy of Sciences-National Research Council Twin Registry: Ten years of operations. In Nance, W. E. (ed.)Twin Research, Part B, Biology and Epidemilogy, Alan R. Liss, New York.

    Google Scholar 

  • Hrubec, Z., and Omenn, G. S. (1981). Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: Twin concordances for alcoholism and its biological points by zygosity among male veterans.Alcohol. Clin. Exp. Res. 5:207–215.

    Google Scholar 

  • Jardine, R., and Martin, N. G. (1984) Causes of variation in drinking habits in a large twin sample.Acta Genet. Med. Gemellol. 33:435–450.

    Google Scholar 

  • Joreskog, K. G., and Sorbom, D. (1993a).New Features in Lisrel 8, Scientific Software International, Chicago,

    Google Scholar 

  • Joreskog, K., and Sorbom, D. (1993b)PRELIS 2 User's Reference Guide, Scientific Software, Chicago.

    Google Scholar 

  • Kaij, L. (1960).Alcoholism in Twins: Studies on the Etiology and Sequels of Abuse of Alcohol, Almqvist & Wiksell, Stockholm.

    Google Scholar 

  • Kaprio, J., Sarna, S., Koskenvuo, M., and Rantasalo, I. (1978).The Finnish Twin Registry: Baseline Characteristics, Section II, university of Helsinki Press, Helsinki.

    Google Scholar 

  • Kendler, K. S. (1993) Twin studies of psychiatric illness: Current status and future directions.Arch. Gen. Psychiat. 50:905–915.

    Google Scholar 

  • Kendler, K. S., Heath, A. C., Neale, M. C., Kessler, R. C., and Eaves, L. J. (1992) A population-based twin study of alcoholism in women.JAMA 268:1877–1882.

    Google Scholar 

  • Kendler, K. S., Neale, M. C., Health, A. C., Kessler, R. C., and Eaves, L. J. (1994). A twin-family study of alcoholism in women.Am. J. Psychiat. 151:707–715.

    Google Scholar 

  • Koskenvuo, M., Langinvainio, J., Kaprio, J., Lonnqvist, J., and Tienan, P. (1984). Psychiatric hospitalization in twins.Acta Genet Med. Gemellol. 33:321–332.

    Google Scholar 

  • Li, T. K. (1990). Genetic animal models for the study of alcoholism. In Cloninger, C. R., and Begleiter, H. (eds.),Banbury Report 33: Genetics and Biology of Alcoholism, Cold Spring Harbor Laboratory Press, Plainview, NY, pp. 217–223.

    Google Scholar 

  • Loehlin, J. C. (1992).Genes and Environment in Personality Development: Individual Differences and Development Series, Vol. 2, Sage, Newbury Park, CA.

    Google Scholar 

  • Madden, P. A. F., Health, A. C., Bucholz, K. K., Dinwiddie, S. H., Dunne, M. P., and Martin, N. G. (1993). Genetics an smoking. Paper presented at the 55th annual meeting of the College on Problems of Drug Dependence, Toronto, Canada, June 12–17.

  • Marks, M. J., Stitzek, J. A., and Collins, A. C. (1986). Doseresponse analysis of nicotine tolerance and receptor changes in two inbred mouse strains.J. Pharmacol. Exp. Ther 239:358–364.

    Google Scholar 

  • Medlund, P., Cederlof, R., Floderus-Myrhed, B., Friberg, L., and Sorensen, S. (1977). A new Swedish twin registry.Acta Med. Scand. Suppl 600.

  • Meyer, J. M., Eaves, L. J., Heath, A. C., and Martin, N. G., (1991). Estimating genetic influences on the age-at-menarche: A survival analysis approach.Am. J. Med. Genet. 39:148–154.

    Google Scholar 

  • Neale, M. C., and Cardon, L. R. (1992).Methodology for Genetic Studies of Twins and Families, NATO ASI Series, Kluwer Academic, Dordrecht, The Netherlands.

    Google Scholar 

  • Peto, R., Lopez, A. D., Boreham, J., Thun, M., and Heath, C. (1992). Mortality from tobacco in developed countries: Indirect estimation from national vital statistics.Lancet 339:1268–1278.

    Google Scholar 

  • Plomin, R., Owen, M. J., and McGuffin, P. (1994). The genetic basis of complex human behaviors.Science 264:1733–1739.

    Google Scholar 

  • Pomerleau, O. F., Collins, A. C., Shiffman, S., and Pomerleau, C. S. (1993a). Why some people smoke and others do not: New perspectives.J. Consult. Clin. Psychol. 61:723–731.

    Google Scholar 

  • Pomerleau, O. F., Hariharan, M., Pomerleau, C. S., Cameron, O. G., and Guthrie, S. K. (1993b). Differences between smokers and nerver-smokers in sensitivity to nicotine: A preliminary report.Addiction 88:113–118.

    Google Scholar 

  • Raaschou-Nielsen, E. (1960). Smoking habits in twins.Danish Med. Bull. 7:82–88.

    Google Scholar 

  • Robins, L. N., and Regier, D. A. (1991).Psychiatric Disorders in America, Free Press, New York.

    Google Scholar 

  • Romanov, K., Kaprio, J., Rose, R. J., and Koskenvuo, M. (1991). Genetics of alcoholism: Effects of migration on concordance rates among male twins.Alcohol Alcohol. Suppl. 1:137–140.

    Google Scholar 

  • SAS Institute, Inc. (1989).SAS/STAT User's Guide, Version 6, 4th ed., SAS Institute, Inc., Cary, NC.

    Google Scholar 

  • Schuckit, M. A. (1994). A prospective study of sons of alcoholics. Presented at Seventh Congress of the International Society for Biomedical Research on Alcoholism, June 26–July 1, Queensland, Australia.

  • Sher, K. J. (1991).Children of Alcoholics. A Critical Appraisal of Theory and Research, University of Chicago Press, Chicago.

    Google Scholar 

  • Tarter, R. E., Hegedus, A. M., Goldstein, G., Shelly, G., and Alterman, A. I. (1984). Adolescent sons of alcoholics: Neuropsychological and personality characteristics.Alcohol. Clin. Exp. Res. 8, 216–222.

    Google Scholar 

  • Treloar, S. (1993). Unpublished Ph.D. thesis, University of Queensland, Australia.

  • Turner, J. R., Cardon, L. R., and Hewitt, J. K. (1994).Behavior Genetic Applications in Behavioral Medicine Research, Plenum, New York (in press).

    Google Scholar 

  • U.S. Department of Health, Education and Welfare (1979).Smoking and Health: A Report of the Surgeon General, Public Health Service, Office of Health, DHEW Publication No. 79-50066, Rockville, MD.

    Google Scholar 

  • U.S. Department of Health and Human Services (1986).The Health Consequences of Involuntary Smoking: A Report of the Surgeon General, Public Health Service Office on Smoking and Health, DHHS Publication No. 97-8398, Rockville, MD.

    Google Scholar 

  • U.S. Department of Health and Human Services (1989).Reducing the Health Consequences of Smoking: 25 Years of Progress, Report of the Surgeon General, Public Health Service, Centers for Disease Control Office on Smoking and Health, DHHS Publication No. 89-8411, Rockville, MD.

    Google Scholar 

  • Vogler, G. P., and Fulker, D. W. (1983). Familial resemblance for educational attainment.Behav. Genet. 13: 341–354.

    Google Scholar 

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Heath, A.C., Madden, P.A.F., Slutske, W.S. et al. Personality and the inheritance of smoking behavior: A genetic perspective. Behav Genet 25, 103–117 (1995). https://doi.org/10.1007/BF02196921

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