Abstract
A cigarette which heats rather than burns tobacco (Premier) was introduced in 1988, but was unacceptable due to unpleasant taste and low nicotine intake. We examined availability of nicotine from a new version (Eclipse), in the same four subjects as our earlier Premier study. Average blood nicotine boosts of 23.7 and 17.8 ng/ml were obtained from smoking a first and second Eclipse. This substantially exceeds intake from Premier (boost 13 ng/ml) and that obtained by heavy smokers from conventional brands (boost 12–15 ng/ml). Eclipse (or similar product) may be the best option for averting Peto’s dire warnings of rising millions of annual smoking deaths in the 2020 s, and its potential for large-scale, long-term switching warrants further study.
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Received: 24 April 1998/Final version: 28 May 1998
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Stapleton, J., Russell, M., Sutherland, G. et al. Nicotine availability from Eclipse tobacco-heating cigarette. Psychopharmacology 139, 288–290 (1998). https://doi.org/10.1007/s002130050719
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DOI: https://doi.org/10.1007/s002130050719