Mouth versus deep airways absorption of nicotine in cigarette smokers☆
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Cited by (41)
Elucidating nicotine transfer into water environments via cigarette butt remaining parts
2024, Environmental PollutionChallenges involved in the creation of scientific evidence for tobacco control
2024, Studies in Natural Products ChemistryDevelopment and Validation Of A Discriminatory Dissolution Method for Portioned Moist Snuff and Snus
2022, Journal of Pharmaceutical SciencesCitation Excerpt :Products pH may determine relative proportion of the ionized and unionized forms of the nicotine, which may influence extent of buccal absorption. Previous research has reported almost no buccal absorption from cigarettes containing flue-cured tobacco (pH ∼5.5) even when held in the mouth.24 On the other hand, good buccal absorption has been observed from air-cured tobacco (pH >6.5).25
History repeats itself: Role of characterizing flavors on nicotine use and abuse
2020, NeuropharmacologyImpact of e-liquid flavors on e-cigarette vaping behavior
2018, Drug and Alcohol DependenceCitation Excerpt :The pH of combustible cigarette smoke affects the site of nicotine absorption. Smoking cigarettes with acidic smoke (∼pH of 5.5) results in nicotine absorption exclusively through the airways below the oropharynx and very little buccal absorption (Gori et al., 1986). At higher pH, nicotine is more readily absorbed buccally, such as from cigar smoke (∼pH 8.5) (Armitage and Turner, 1970).
Differences in nicotine dependence, smoke exposure and consumer characteristics between smokers of machine-injected roll-your-own cigarettes and factory-made cigarettes
2018, Drug and Alcohol DependenceCitation Excerpt :The differences in cotinine were not due to the weight of the tobacco in the cigarettes, which were similar in RYO and FM. However, studies from several decades ago found mouth-level absorption from pipe tobacco due to its higher alkaline pH content whereas cigarette tobacco smoke absorption occurs entirely in the lungs (Elson and Betts, 1972; Gori et al., 1986). Further work is needed to determine whether this might explain the lower cotinine in RYO smokers.
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Research supported in part by United States Public Health Services Grant No. DA02277, DA01696 and CA32389.