Environmental tobacco smoke: overview of chemical composition and genotoxic components
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Tobacco, nicotine, health, and mental health
2023, Encyclopedia of Mental Health, Third Edition: Volume 1-3Phenotypic and transcriptomic changes in the corneal epithelium following exposure to cigarette smoke
2021, Environmental PollutionInfluence of the environmental relative humidity on the inflammatory response of skin model after exposure to various environmental pollutants
2021, Environmental ResearchCitation Excerpt :For several years, works agreed that Tobacco Smoke (TS) has a strong impact on the skin. TS is a complex mixture of over 4000 compounds (CO, HCN, benzene, formaldehyde, nicotine, phenol, polycyclic aromatic hydrocarbons, etc.) and only the particulate phase, which represents approximately 5% of the cigarette's total output, is visible as smoke (Hoffmann et al., 1997; Löfrth, 1989; Auer et al., 2017). This complex mixture leads to premature skin aging, wrinkling, poor wound healing, squamous cell carcinoma, and chronic dermatoses (Ortiz and Grando, 2012).
GSTP1 c.341C>T gene polymorphism increases the risk of oral squamous cell carcinoma
2018, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :Toxicological importance of GST pi is also corroborated by animal studies. Epoxides of Polycyclic aromatic hydrocarbons (PAH) such as Benzo(a)pyrene [B(a)P] diolepoxide(BPDE), acrolein and other unsaturated carbonyls generated by oxidation of lipids and DNA can be used as substrates by GST pi [22]. Mice with GSTP1 knock out show increased risk of skin cancer when exposed to carcinogens like polycyclic aromatic hydrocarbons [23].