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Cigar, pipe, and cigarette smoking and bladder cancer risk in European men

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Abstract

Objective: Estimating the risk of bladder cancer from cigar and pipe smoking is complicated by a small number of non-cigarette smokers included in most relevant studies.

Methods: We undertook a pooled analysis of the data on men from six published case–control studies from Denmark, France, Germany, and Spain, to assess the association between pipe and cigar smoking and bladder cancer, and to compare it with the risk from cigarette smoking. Complete history of tobacco smoking was ascertained separately for cigarettes, cigars, and pipe. Odds ratios (ORs) were estimated after adjusting for age, study, and employment in high-risk occupations.

Results: The pooled data set comprised 2279 cases and 5268 controls, of whom 88 cases and 253 controls smoked only cigars or pipe. The OR for pure cigarette smoking was 3.5 (95% confidence interval [CI] 2.9–4.2), that for pure pipe smoking was 1.9 (95% CI 1.2–3.1) and that for pure cigar smoking was 2.3 (95% CI 1.6–3.5). The increase in the OR of bladder cancer that was observed with duration of smoking was non-significantly lower for cigars than for cigarettes.

Conclusion: Our results suggest that smoking of cigars and pipe is carcinogenic to the urinary bladder, although the potency might be lower than for cigarettes.

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References

  1. International Agency for Research on Cancer (1986) Tobacco Smoking. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, vol. 38. Lyon: IARC.

    Google Scholar 

  2. Dolin PJ (1991) An epidemiological review of tobacco use and bladder cancer. J Smoking Rel Dis 2: 129–143.

    Google Scholar 

  3. Schwartz D, Flamant R, Lellouch J, Denoix PF (1961) Results of a French survey on the role of tobacco, particularly inhalation, in different cancer sites. J Natl Cancer Inst 26: 1085–1108.

    Google Scholar 

  4. Morrison AS, Buring JE, Verhoek WG, et al. (1984) An international study of smoking and bladder cancer. J Urol 131: 650–654.

    Google Scholar 

  5. Hartge P, Hoover R, Kantor A (1985) Bladder cancer risk and pipes, cigars, and smokeless tobacco. Cancer 55: 901–906.

    Google Scholar 

  6. Slattery ML, Schumacher MC, West DW, Robinson LM (1988) Smoking and bladder cancer: the modifying effect of cigarettes on other factors. Cancer 61: 402–408.

    Google Scholar 

  7. Burch JD, Rohan TE, Howe GR, et al. (1989) Risk of bladder cancer by source and type of tobacco exposure: a case-control study. Int J Cancer 44: 622–628.

    Google Scholar 

  8. Shanks TG, Burns DM (1998) Disease consequences of cigar smoking. In: Cigars: Health Effects and Trends (Smoking and Tobacco Control Monograph no. 9). Washington, DC: US Department of Health and Human Services (Publ. No. NIH 98-4302), pp. 105–158.

    Google Scholar 

  9. Iribarren C, Tekawa IS, Sidney S, Friedman GD (1999) Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease, and cancer in men. N Engl J Med 340: 1773–1780.

    Google Scholar 

  10. Boffetta P, Pershagen G, Jöckel KH, et al. (1999) Cigar and pipe smoking and lung cancer risk: a multicenter study from Europe. J Natl Cancer Inst 91: 697–701.

    Google Scholar 

  11. Claude J, Kunze E, Frentzel-Beyme R, Paczkowski K, Schneider J, Schubert H (1986) Life-style and occupational risk factors in cancer of the lower urinary tract. Am J Epidemiol 124: 578–589.

    Google Scholar 

  12. Jensen OM, Wahrendorf J, Blettner M, Knudsen JB, Sorensen BL (1987) The Copenhagen case-control study of bladder cancer: role of smoking in invasive and non-invasive bladder tumours. J Epidemiol Commun Health 41: 30–36.

    Google Scholar 

  13. Clavel J, Cordier S, Boccon-Gibod L, Hemon D (1989) Tobacco and bladder cancer in males: increased risk for inhalers and smokers of black tobacco. Int J Cancer 44: 605–610.

    Google Scholar 

  14. Lopez-Abente G, Gonzalez CA, Errezola M, et al. (1991) Tobacco smoke inhalation pattern, tobacco type, and bladder cancer in Spain. Am J Epidemiol 134: 830–839.

    Google Scholar 

  15. Greiser E, Molzhan M, eds (1997) Multizentrische Nieren-und Urothel-Carcinom-Studie (Abschlussbericht). Dortmund: Schriftenreihe der Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin-Forschung-FB780.

    Google Scholar 

  16. Serra C, Bonfill X, Sunyer J, et al. (2000) Bladder cancer in the textile industry. Scand J Work Environ Health 26: 474–479.

    Google Scholar 

  17. Mannetje A 't, Kogevinas M, Chang-Claude J, et al. (1999) Occupation and bladder cancer in European women. Cancer Causes Control 10: 209–217.

    Google Scholar 

  18. Stata Corporation (1997) Stata Statistical Software, Release 5.0. College Station, TX: Stata Corporation.

    Google Scholar 

  19. Cartwight RA, Glashan RW, Rogers HJ, et al. (1982) Role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer. Lancet 2: 842–845.

    Google Scholar 

  20. Mommsen S, Aagaard J (1986) Susceptibility in urinary bladder cancer: acetyltransferase phenotypes and related risk factors. Cancer Lett 32: 199–205.

    Google Scholar 

  21. Bartsch H, Malaveille C, Friesen M, Kdulbar FF, Vineis P (1993) Black (air-cured) and blond (flue-cured) tobacco and cancer risk. IV: Molecular dosimetry studies implicate aromatic amines as bladder carcinogens. Eur J Cancer 29A: 1199–1207.

    Google Scholar 

  22. Vineis P, Esteve J, Hartge P, Hoover R, Silverman DT, Terracini B (1988) Effects of timing and type of tobacco in cigarette-induced bladder cancer. Cancer Res 48: 3849–3852.

    Google Scholar 

  23. Wynder EL, Stellman SD (1997) Comparative epidemiology of tobacco related cancers. Cancer Res 37: 4608–4622.

    Google Scholar 

  24. Wald NJ, Watt HC (1997) Prospective study of effect of switching from cigarettes to pipes or cigars on mortality from three smoking related diseases. BMJ 314: 1860–1863.

    Google Scholar 

  25. Nicolaides-Bouman A, Wald N, Forey B, Lee P (1993) International Smoking Statistics: A Collection of Historical Data from Economically Developed Countries. Oxford: Oxford University Press.

    Google Scholar 

  26. Anon (1997) Cigar smoking among teenagers — United States, Massachusetts, and New York, 1996. Morb Mortal Wkly Rep 46: 433–440.

  27. Gerlach KK, Cummings KM, Hyland A, Gippin EA, Johnson MD, Pierce JP (1998) Trends in cigar consumption and smoking prevalence. In: Cigars: Health Effects and Trends (Smoking and Tobacco Control Monograph no. 9). Washington, DC: US Department of Health and Human Services (Publ. No. NIII 98-4302), pp. 21–53.

    Google Scholar 

  28. Nelson DE, Davis RM, Chrismon JH, Giovino GA (1996) Pipe smoking in the United States, 1965–1991: prevalence and attributable mortality. Prev Med 25: 91–99.

    Google Scholar 

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Pitard, A., Brennan, P., Clavel, J. et al. Cigar, pipe, and cigarette smoking and bladder cancer risk in European men. Cancer Causes Control 12, 551–556 (2001). https://doi.org/10.1023/A:1011291015233

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