Abstract
We investigated tobacco industry documents and other sources for evidence of possible pharmacological and chemical effects of tobacco additives. Our findings indicated that more than 100 of 599 documented cigarette additives have pharmacological actions that camouflage the odor of environmental tobacco smoke emitted from cigarettes, enhance or maintain nicotine delivery, could increase the addictiveness of cigarettes, and mask symptoms and illnesses associated with smoking behaviors. Whether such uses were specifically intended for these agents is unknown. Our results provide a clear rationale for regulatory control of tobacco additives.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Ammonia / adverse effects
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Ammonia / analysis
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Animals
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Behavior, Addictive* / physiopathology
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Brain / drug effects*
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Brain / physiopathology
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Cognition / drug effects
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Drug Synergism
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Electroencephalography
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Evoked Potentials
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Humans
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Nicotiana / adverse effects
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Nicotiana / chemistry*
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Nicotine / adverse effects*
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Nicotine / metabolism*
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Nicotinic Agonists / adverse effects
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Nicotinic Agonists / analysis
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Plants, Toxic* / adverse effects
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Smoking / adverse effects
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Smoking / epidemiology*
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Tobacco Industry*
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Tobacco Smoke Pollution / analysis
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United States / epidemiology
Substances
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Nicotinic Agonists
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Tobacco Smoke Pollution
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Nicotine
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Ammonia