Background No systematic attempts have been made to estimate the global and regional
prevalence of amphetamine, cannabis, cocaine, and opioid dependence, and quantify their …

Cannabis use disorder (CUD) is an underappreciated risk of using cannabis that affects~
10% of the 193 million cannabis users worldwide. The individual and public health burdens …

Tobacco smoking is a major determinant of preventable morbidity and mortality worldwide.
More than a billion people smoke, and without major increases in cessation, at least half will …

Abstract The Alcohol Use Disorders Identification Test (AUDIT) is a 10–item questionnaire
designed by the World Health Organization to screen for hazardous alcohol intake in …

Background Medicinal cannabinoids, including medicinal cannabis and pharmaceutical
cannabinoids and their synthetic derivatives, such as tetrahydrocannabinol (THC) and …

Substance use in young people (aged 10–24 years) might disrupt key periods of transition
that occur as the adolescent brain undergoes cognitive and emotional development, and …

This review examines evidence for the effectiveness of cannabinoids in chronic noncancer
pain (CNCP) and addresses gaps in the literature by: considering differences in outcomes …

We did a systematic review of reviews with evidence on the effectiveness of prevention,
early intervention, harm reduction, and treatment of problem use in young people for …

Alcohol use disorders are common in developed countries, where alcohol is cheap, readily
available, and heavily promoted. Common, mild disorders often remit in young adulthood …

Aims Estimate the prevalence of cannabis dependence and its contribution to the global
burden of disease. Methods Systematic reviews of epidemiological data on cannabis …