Tobacco use is associated with 5 million deaths per year worldwide and is regarded as one
of the leading causes of premature death. Comprehensive programmes for tobacco control …

Tobacco products present a deadly combination of nicotine addiction and carcinogen
exposure resulting in millions of cancer deaths per year worldwide. A plethora of smokeless …

The harm produced by tobacco products is a result of frequent use of a highly toxic product.
Reducing the adverse public health impact of tobacco products might be most effectively …

The topic of e-cigarettes is controversial. Opponents focus on e-cigarettes' risks for young
people, while supporters emphasize the potential for e-cigarettes to assist smokers in …

Importance The optimal temporal approach for reducing nicotine to minimally or
nonaddictive levels in all cigarettes sold in the United States has not been determined …

Objective.—To review and discuss the differences and similarities between the use of crack
cocaine and cocaine hydrochloride; and to determine how these findings might affect …

Background The Food and Drug Administration can set standards that reduce the nicotine
content of cigarettes. Methods We conducted a double-blind, parallel, randomized clinical …

To investigate sex and menstrual cycle effects in response to cocaine administration, data
from existing studies were analyzed. First, responses to a single delivery of 0.4 mg/kg …

Introduction: Electronic cigarettes (e-cigarettes) are rapidly increasing in popularity but little
information is available on their potential toxic or carcinogenic effects. Methods: Twenty …

We quantified urinary levels of two metabolites of the tobacco-specific lung carcinogen 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in people who had stopped smoking: 4 …