Article Text

Download PDFPDF

Sociodemographic predictors of success in smoking intervention
  1. E Monsóa,
  2. J Campbellb,
  3. P Tønnesenc,
  4. G Gustavssonb,
  5. J Moreraa
  1. aServei de Pneumologia, Hospital Germans Trias I Pujol, Badalona, Catalonia, Spain, bPharmacia and Upjohn, Sant Cugat del Vallés, Spain, and Helsingborg, Sweden, cDepartment of Pulmonary Medicine, Gentofte Hospital, Hellerup, Denmark
  1. Dr Eduard Monsó, Servei de Pneumologia, Hospital Germans Trias I Pujol, Cra. del Canyet s/n, Ap. de correus 72, 08916 Badalona, Catalonia. Spainemonso{at}


AIM To examine the role of sociodemographic factors as predictors of sustained smoking cessation for the population who volunteer to participate in intervention programmes.

METHOD Data for the 3575 smokers who participated in the CEASE (collaborative European anti-smoking evaluation) trial, a European multicentred study that used transdermal nicotine patches as an adjunct to smoking cessation in the chest clinic, were analysed. The effects of age, sex, smoking habit, socioeconomic status (housing conditions, education, and employment), disease, smoking habits of relatives, and baseline markers of tobacco use on sustained smoking cessation (self-reported abstinence and expired carbon monoxide < 10 parts per million) were assessed using logistic regression modelling (odds ratio (OR), 95% confidence interval (CI)).

RESULTS 477/3575 smokers were sustained abstainers one year after the intervention (overall success rate 13.3%). In the univariable logistic regression models an effect of active treatment on smoking cessation was observed (OR 1.50, 95% CI 1.15 to 1.96), and additional effects on outcome were found for age (OR 1.02, 95% CI 1.01 to 1.03), sex (menv women: OR 1.38, 95% CI 1.14 to 1.68), housing conditions (OR 1.43, 95% CI 1.25 to 1.65), current respiratory (OR 0.79, 95% CI 0.67 to 0.92) or cardiac disease (OR 0.46, 95% CI 0.28 to 0.75), and markers of tobacco use (cigarettes per day: OR 0.79, 95% CI 0.69 to 0.90; expired carbon monoxide: OR 0.98, 95% CI 0.97 to 0.99). Education and employment did not have a significant effect on the outcome. The effect of the variables associated with success in smoking cessation persisted after adjustment for covariates.

CONCLUSION Age, sex, and housing conditions have a major effect on smoking cessation in European smokers participating in smoking cessation programmes.

  • cessation
  • sociodemographic predictors

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Age, sex, socioeconomic status, and nicotine dependence are well defined determinants of success in smoking cessation for the general population.1 2 The impact of these factors on success rates, however, has rarely been investigated for participants in smoking intervention programmes. The wide range of abstinence rates attained in these programmes has been attributed to non-specified characteristics of the target population or to methodology. In smoking cessation the nicotine patch and other nicotine products have proven useful, as shown by increases in the proportion of smokers who quit.3 4 The limited information on the predictors of success in smoking intervention makes it difficult to adjust programmes to target populations, a necessary requirement for achieving the maximum possible benefit, under the assumption that populations with specific sociodemographic characteristics would need to be targeted appropriately, independently of their degree of motivation.5 6

In the present study we have examined the role of different sociodemographic factors as predictors of successful smoking cessation in the sample of smokers from 17 European countries that were enrolled in the CEASE (collaborative European anti-smoking evaluation) trial, a study that examined the effect of a smoking intervention programme using the nicotine patch.4



The CEASE trial was a placebo controlled, double blind study that used transdermal nicotine patches as an adjunct to smoking cessation advice in the chest clinic. Subjects who had been smoking ⩾ 15 cigarettes/day for at least three years were recruited from the general population on a voluntary basis and randomly allocated to one of five treatment arms, four with nicotine and one with placebo. The four active treatment arms applied different dosages and durations of treatment. All active treatments were followed by a tapering off period of one month. Details of the study protocol and success rates of each treatment arm one year after enrollment have been published elsewhere.4 In the present paper we examine the role of sociodemographic factors as predictors of sustained smoking cessation in the CEASE trial.


Following advertising in local media, smokers aged 20–70 years were recruited at 36 centres in 17 European countries.4Participants had to have made at least one prior attempt to quit. Exclusion criteria were acute cardiac disease within the last three months, pregnancy, breast feeding, current psychiatric disease, alcohol or any other drug abuse, eczema or malignant disease.

At baseline subjects were required to stop smoking completely on the target day for quitting, and they received a brochure containing advice on smoking cessation and nicotine patch therapy. Subjects in the treatment groups used nicotine patches containing 0.83 mg/cm2 of nicotine for 16 hours (Nicorette, Pharmacia and Upjohn, Helsingborg, Sweden).7 Subjects in the placebo group received the same patches without nicotine. Strong advice on refraining from smoking was given at the seven scheduled follow up visits.


At enrollment, subjects who entered the study answered a questionnaire that included questions on age, sex, parental smoking, age when cigarette use started, current number of cigarettes smoked per day, previous attempts to quit, presence of other smokers in the household, and former and current diseases. Furthermore, the following measurements were performed: (1) carbon monoxide (CO) concentration in expired air after 15 seconds of breath holding (Bedfont Monitor, Sittingbourne, UK); (2) Fagerström test for nicotine dependence (FTND) (score 0–10 reflecting least to most dependence)8; and (3) plasma nicotine and cotinine concentrations, analysed using gas chromatography.9 Self-reported cigarette consumption and expired CO were also measured at all follow up visits, because the outcome variable was sustained abstinence, defined as self-defined complete abstinence from week 2 to month 12, with an expired CO < 10 parts per million (ppm) at visit 2 and all following visits. Subjects who did not fulfil these criteria were considered failures, as were subjects who did not attend all follow up visits.

Socioeconomic status was measured at baseline using a questionnaire covering housing conditions, education, and employment. Housing conditions included questions about rented or owned home (scoring 0 and 1, respectively), number of years in the present home (ordinal variable categorised as 0–1, 2–4, 5–10, and > 10) and person per room ratio (ordinal variable with four categories from more to fewer persons per room). A composite variable for housing conditions was also created by combining the answers to these three questions. Education was recorded as the education level attained when schooling was finished (ordinal variable categorised as primary, secondary/high school, higher than secondary/ high school, and postgraduate). Employment was recorded as unemployed or employed and occupation as blue collar and white collar.


Although there were large differences in the overall outcome across the 36 centres participating in the study, there was no significant heterogeneity between them in terms of success rate of active versus placebo treatment, as reported elsewhere4; accordingly, all analyses were conducted on the pooled data from all centres.

The main outcome variable was sustained smoking cessation. The possible predictors of sustained smoking cessation were age, sex, parental smoking (categorised as absent or present), age when smoking started (ordinal variable with four categories), number of smoked cigarettes per day (ordinal variable categorised as ⩽ 20, 21–30 or > 30), number of attempts to quit (continuous variable), respiratory, cardiac or other chronic diseases, history of depression, presence of other smokers in the household (all five variables categorised as absent or present), socioeconomic status (housing conditions, education, employment and occupation), baseline expired CO (ordinal variable categorised as 0–20, 21–40 or > 40 ppm), FTND score, and blood nicotine and cotinine concentrations (all three expressed as continuous variables). A descriptive analysis was performed first, with categorical variables expressed as proportions and continuous variables as mean (SD) unless specified. After that, occupation was discarded for the analysis because of insufficient data available to classify the subject as blue or white collar in one third of the population sample. Inferential statistical analysis was then performed, considering the main outcome as the dependent variable and the specified predictors as independent variables. Success rates obtained for the studied predictors were calculated and univariable logistic regression models were created. Variables that showed significance (p < 0.10) in the univariable models were entered in a multivariable stepwise multiple logistic regression model to determine the odds ratios (OR) and 95% confidence intervals (95% CI) for sustained abstinence of the different predictors. Considering the colinearity between FTND score, baseline expired CO, and blood nicotine/cotinine concentrations, only the variable showing the strongest association with the outcome was included in the multivariable model. All statistical tests were two sided, and a probability value of p ⩽ 0.05 was reported as significant. The study was approved by the ethics committee of every institution.


After a follow up of 12 months, 477 of the 3575 smokers enrolled in the study were sustained abstainers (overall success rate 13.3%). The descriptive characteristics of the population sample are reported in tables 1 and 2, together with the success rates for specific subgroups.

Table 1

Descriptive statistics: continuous variables (n = 3575)

Table 2

Descriptive statistics: categoric variables (n = 3575)

When the different predictors of sustained abstinence were assessed in univariable logistic regression models (table 3), a clear cut effect of active nicotine patch treatment on the success rate was observed (OR 1.50, 95% CI 1.15 to 1.96). Age and sex were also predictors of sustained smoking cessation, with higher success rates in older subjects and men. Smokers with respiratory or cardiac disease had lower success rates when compared with smokers not suffering these diseases. A negative effect of other chronic diseases or a history of depression was not evident in the study, however. The number of cigarettes consumed per day was a clear predictor of sustained abstinence, with a higher success rate when the subject smoked less cigarettes per day. This effect was also evident when biochemical markers of tobacco use were examined, with a highest probability of sustained abstinence associated with lower concentrations of expired CO, and blood nicotine and cotinine. Similarly, the FTND score also predicted sustained abstinence, with an increase in success rate for smokers with lower scores. Housing conditions, considered to be a marker of income and social factors, were strong socioeconomic predictors of success, with higher success rates for smokers who owned their houses, had longer residence periods in their households, and fewer persons per room. The other socioeconomic variables assessed in our study, educational level and employment, were not clinically significant determinants of success, however. When all significant predictors of the outcome were assessed in a multivariable model, the associations observed in the univariable models did not change significantly, and nicotine treatment, age, sex, cigarettes per day, cardiorespiratory disease, housing conditions, and expired CO persisted as significant predictors of smoking cessation for the population sample who volunteer to participate in the CEASE trial (table 3).

Table 3

Predictors of sustained smoking cessation


In the present study age, sex and housing conditions emerged as clear cut predictors of smoking cessation for the subjects who volunteer to participate in a European smoking cessation intervention programme, with higher success rates for males and older subjects who owned their home and have longer residence periods in their household. Sustained abstinence emerged to be more difficult for subjects who have developed cardiopulmonary disease. Certain markers of tobacco use also proved to be associated with success: subjects smoking more cigarettes with high CO concentrations in expired air attained smoking cessation less often.

Several studies have shown that age and sex are important determinants of smoking cessation in the general population. Higher success rates have been commonly reported for older subjects,1 5 10 11 and age has been currently considered a main confounder when other predictors of smoking cessation were analysed.12 Differences in smoking prevalence according to sex have been reported in Europe and North America in the last decades, together with higher smoking cessation rates in men, probably related both to differences of conditioning effects and nicotine dependence patterns between the sexes.1 12-14Some specific characteristics of smoking cessation in women have emerged clearly from the studies that have examined cessation during pregnancy, often showing lower than expected long term success rates.15

Sociodemographic characteristics may have a greater impact on smoking cessation in smokers who volunteer to be included in intervention programmes than in the general population. In fact, subjects participating in smoking cessation programmes often are not representative of the general population. As we have shown in our study, more than 60% of smokers enrolled in the CEASE trial had followed education beyond secondary/high school, suggesting that the population participating in smoking cessation intervention programmes is self-selected, with an under representation of subjects with primary education. This selection determines that predictors of success in intervention programmes may be different from predictors for the general population. In the Lung Health Study, a clinical trial that enrolled approximately 4000 subjects in an intensive smoking intervention programme, a sex difference in the one year smoking cessation rates was not observed, but a higher relapse rate for women emerged three years after the intervention.16 Similarly, in our study we have found a higher success rate for men, evident one year after the intervention, that persisted after adjusting for covariates (OR 1.52, 95% CI 1.22 to 1.88). These two observations suggest that success in smoking cessation programmes is more difficult for women than for men, a difference that health care planners need to take into account.

Socioeconomic status is usually considered to be derived from a combination of education, income, and occupation,17 18but the way to measure these components has not been standardised, and different approaches to its measurement may be the cause of the reported differences in the impact of socioeconomic status on health variables.19 A high impact of some housing related components of socioeconomic status on smoking cessation emerged from our study, with higher success rates associated with better housing conditions (OR 1.29, 95% CI 1.11 to 1.51). Subjects who owned their home, had a low person per room ratio, and lived in the same household for longer periods were more often successful. Other components of socioeconomic status, however, did not seem to have the same impact on smoking cessation in our study. Education had no impact on the outcome, perhaps because of the difficulty of applying educational categories that are meaningful across countries with different educational systems, or because of under representation of subjects with primary studies in the CEASE trial. Our results suggest that the effect of education on smoking cessation may be low for subjects participating in intervention programmes, because subjects who attained higher education levels are over represented in the population who volunteered to participate. In population based studies higher education has been a predictor of success in smoking cessation,5 10 20 21and this effect of education has also been reported in some intervention studies.22 In our study we have not found an effect of employment on smoking cessation, a finding similar to those of other studies that have not reported a significant impact of unemployment on the change in smoking habits.23

What this paper adds

Age, sex, socioeconomic status, and nicotine dependence are well defined determinants of success in smoking cessation for the general population, but the impact of sociodemographic factors on success rates has been rarely investigated for participants in smoking intervention programmes.  This study shows that European smokers who volunteer to participate in smoking cessation programmes are a self-selected population with over representation of subjects with higher education. The use of nicotine patches improved success rates for this population, but smoking cessation also depends greatly on age, sex, and certain socioeconomic factors. Higher success rates may be expected in males and older subjects with better housing conditions. Sustained smoking cessation was especially difficult for subjects who consumed more tobacco and had developed cardiorespiratory disease.

Several factors related to nicotine dependence were associated with success. Subjects who smoked fewer cigarettes per day and had lower concentrations of the biochemical markers of tobacco use (expired CO and blood cotinine/nicotine) had higher success rates, as has been reported by other authors.5 10 21 Subjects with respiratory and/or cardiac diseases had lower success rates, and these diseases may probably be considered in some way markers of dependence, because subjects with low nicotine dependence often quit shortly after the first appearance of smoking related symptoms, not allowing for the progression to chronic disease. The difficulty in refraining from smoking has been also reported for the smokers with respiratory symptoms who enrolled in the Lung Health Study.22

The FTND score was a less powerful predictor of sustained abstinence than biochemical markers of tobacco use such as expired CO. The FTND has been validated against objective measures of tobacco use8 but it is not unexpected that it correlates less well with success than do other measures of tobacco use.24 In fact, the main advantage of the FTND is that it can be used easily in the clinic without any blood sampling or use of complementary devices. The low predictive power of dependence questionnaires for smoking cessation, previously reported by other authors,3emphasises the need to use objective measures when a prediction of success in smoking cessation is looked for.

Some studies have reported the impact of cohabiting with non-smokers in smoking cessation.1 5 15 20 25 This effect, however, was not observed in our study. This may be related to the inclusion of a wider set of predictors in the present analysis, which probably revealed the low predictive power of partner smoking when other explicative variables are included in the analysis.

We conclude that European smokers who volunteer to participate in smoking cessation programmes are a self-selected population with over representation of subjects who attained an education level higher than secondary/high school. The use of nicotine patches improves the success rate, but smoking cessation also depends greatly on age, sex, and certain socioeconomic factors. Higher success rates after one year of intervention may be expected in males and older subjects with better housing conditions. Sustained smoking cessation is especially difficult for subjects who consume more tobacco or have developed cardiorespiratory disease.


View Abstract