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Occult maternal exposure to environmental tobacco smoke exposure
  1. Ingrid de Chazeron1,
  2. Pierre-Michel Llorca1,
  3. Sylvie Ughetto2,
  4. François Coudore3,
  5. Didier Boussiron4,
  6. Jean Perriot1,
  7. Françoise Vendittelli5,
  8. Vincent Sapin6,
  9. Didier Lemery6
  1. 1Department of Psychiatry B, CHU Clermont-Ferrand, France
  2. 2Department of Biostatistics, CHU Clermont-Ferrand, France
  3. 3Laboratory of Pharmacology and Toxicology, CHU Clermont-Ferrand, France
  4. 4Sainte Marie Institut, Clermont-Ferrand, France
  5. 5Department of Obstetrics and Gynaecology (Hôtel-Dieu) CHU Clermont-Ferrand, France
  6. 6Biochemistry Department, CHU Clermont-Ferrand, France
  1. Correspondence to:
 I de Chazeron
 Centre Hospitalier Universitaire, CMP-B, Rue Montalembert BP 69, F-63003 Clermont-Ferrand Cedex 1, France; idechazeron{at}


Background: Environmental tobacco smoke (ETS) is a recognised air pollutant. Its harmful effects have been found to be implicated in health disorders, including unfavourable pregnancy outcomes. The discrepancy between self-reported emvironmental tobacco smoke exposure and cotinine levels in pregnant non-smokers in France was examined.

Method: Plasma cotinine was determined by a CPG-SM method on women who had answered a self-questionnaire describing their habits and environment during pregnancy.

Results: Of 698 pregnant women reported as non-smokers, 305 (43.7%) claimed not to be exposed to ETS, yet 196 of these (64.3%) had plasma cotinine levels above the limit of detection.

Conclusion: Self-reported data on ETS exposure in pregnant women therefore underestimate actual exposure. However, cotinine assay cab rectify this misclassification. An accurate identification of this risk factore will help to change attitudes towards ETS and avert its adverse effects on mother and fetus.

  • ETS, environment tobacco smoke
  • LOD, limit of detection

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  • Competing interests: None declared.