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Variable and potentially fatal amounts of nicotine in e-cigarette nicotine solutions
  1. Jennifer M Cameron1,
  2. Donelle N Howell1,
  3. John R White2,
  4. David M Andrenyak3,4,
  5. Matthew E Layton1,
  6. John M Roll1
  1. 1College of Nursing, Program of Excellence in the Addictions, Nursing, Washington State University, Spokane, Washington, USA
  2. 2Department of Pharmacotherapy, College of Pharmacy, Washington State University, Spokane, Washington, USA
  3. 3College of Pharmacy, Center for Human Toxicology, University of Utah, Salt Lake City, Utah, USA
  4. 4College of Pharmacy, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA
  1. Correspondence to Dr Donelle N Howell, Program of Excellence in Addictions, Nursing, Washington State University, PO BOX 1495, Spokane, WA 99210-1495, USA; dnhowell{at}

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Experimental research on electronic cigarettes (e-cigarettes) is sparse. Regulated as tobacco products by the US Food and Drug Administration, e-cigarette safety has not been determined. This enables the sale of e-cigarettes and tobacco-derived nicotine solution to consumers without rigorous safety regulations that would be required if the products were regulated as drug delivery devices.1 As such, despite the recent popularity of e-cigarettes as an alternative to cigarette smoking, consumers currently do not have industry-regulated information on the concentration of e-cigarette solutions or their safety.1 The present study reports the nicotine concentration of several of these solutions.


A convenience sample of seven e-cigarette nicotine solutions was analysed. Samples ranged from prepackaged and sealed with concentration levels printed on the labels to blank bottles with hand-written labels with no concentration level, warning …

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