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The case for the WHO Advisory Note, Global Nicotine Reduction Strategy
  1. Dorothy K Hatsukami1,
  2. Ghazi Zaatari2,
  3. Eric Donny3
  1. 1Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA
  2. 2Department of Pathology and Laboratory Medicine, American University of Beirut, Hamra, Beirut, Lebanon
  3. 3Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  1. Correspondence to Dorothy K Hatsukami, Department of Psychiatry, University of Minnesota, 717 Delaware St SE, Minneapolis, MN 55414, USA; hatsu001{at}

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Cigarettes are the most addictive tobacco product and also the most deadly, causing the highest rates of tobacco-caused mortality and morbidity in most areas of the world.1 ,2 Although current tobacco control efforts have led to significant reductions in smoking prevalence, innovative strategies that can result in a more rapid elimination of cigarette smoking should be a high priority.1 ,3 In the US Surgeon General's report,1 reducing nicotine in cigarettes was considered as one potential strategy. In an article written by Tengs et al,4 in which the authors modelled the effects of reducing nicotine in cigarettes on public health, taking into account a potential black market, the following statement was made: ‘Policy makers would be hard-pressed to identify another domestic public health intervention, short of historical sanitation efforts, that has offered this magnitude of benefit to the population’. Hence, the main goal of the Advisory Note, Global Nicotine Reduction Strategy, issued by the Study Group on Tobacco Product Regulation (TobReg), was to provide a scientific review and examine the potential feasibility of reduced nicotine content cigarettes as an approach to tobacco control, and to describe the context in which this approach could be considered. This approach is bold, but worth serious consideration. Why? Because the tobacco control community has known for decades that the harms associated with smoking are primarily driven by its addictiveness. If the reinforcing effects of a drug are reduced, then continued use and consequently toxicant exposures will substantially diminish. However, this strategy is not suitable for all countries. As acknowledged in …

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  • Funding US National Cancer Institute (U19CA157345) and National Institute on Drug Abuse (U54DA031659).

  • Disclaimer DKH and GZ are members of the WHO Study Group on Tobacco Product Regulation. The content of this commentary are solely the responsibility of the authors and represent the official views of neither the WHO nor the US National Institutes of Health nor the Food and Drug Administration.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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