Footnotes

• ↵i In the MRTP application to the FDA, PMI uses the lower-case ‘iQOS’ as the formal product name. In Korea, PMI uses ‘아이코스” (reads i-co-s) in Korean and ‘IQOS’ in English.

• ↵ii In Japan, IQOS tobacco sticks are marketed as ‘HeatSticks’. PMI also uses ‘Marlboro HeatSticks’ as formal product name in its FDA MRTP application. In Europe and Korea, the tobacco sticks are marketed as ‘HEETS’.

• Funding The author wish to acknowledge the funding support of the Food and Drug Administration/National Cancer Institute (P50CA180890).

• Disclaimer This content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute and the Food and Drug Administration.

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.