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Contributors JGW, ECH, JC and DV contributed to the design of the study. HX and MB performed the analyses. MB, EH and JC contributed to the implementation of the study. JGW, MB and MSG wrote the manuscript. All authors contributed to revising the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Obtained.
Ethics approval Chesapeake IRB, Protocol Number: Pro00023668.
Provenance and peer review Not commissioned; externally peer reviewed.
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