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We have now completed three years of follow up with our cohort and
will be looking at the issues raised above.
I do not feel that tolerance is central to nicotine dependence and I
would not feel that the rate at which tolerance builds up would be a valid
measure of whether these youths are addicted. After all, chippers show no
signs of dependence but do show tolerance. I do not think you can prove
that a measure of dependence is valid by showing that youths who have that
symptom progress more rapidly to higher levels of consumption. We will
look at that however.