PT  - JOURNAL ARTICLE
AU  - Chris Smerecnik
AU  - Janaica E J Grispen
AU  - Marieke Quaak
TI  - Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis
AID  - 10.1136/tc.2011.042739
DP  - 2012 May 01
TA  - Tobacco Control
PG  - 347--354
VI  - 21
IP  - 3
4099  - http://tobaccocontrol.bmj.com/content/21/3/347.short
4100  - http://tobaccocontrol.bmj.com/content/21/3/347.full
SO  - Tob Control2012 May 01; 21
AB  - Objective To examine whether genetic testing for smoking-related diseases benefits smoking cessation.Data sources PubMed, EMBASE, ERIC, PsycINFO, PsychArticles, CiNAHL and socINDEX databases, the search engine Google Scholar, and key-author and reference list searches.Study selection Randomised controlled smoking cessation interventions using genetic testing for smoking-related diseases.Data extraction Consistent with the Cochrane guidelines, two reviewers completed the review process (initial n=139) in three phases, title selection (n=56), abstract selection (n=28) and whole paper selection (n=9). From these nine studies, each reviewer extracted information about outcome measures and statistical and methodological quality.Data synthesis Relevant data were abstracted from included papers and were subsequently subjected to meta-analysis.Results Interest in genetic testing was relatively high with 60-80% of smokers reporting to be interested. The authors observed positive short-term effects on risk perception, motivation to quit smoking and smoking cessation, but these effects fade at longer follow-ups. Importantly, the authors did not find any evidence of adverse effect of testing negative on the risk-predisposing gene.Conclusions This systematic review does not provide solid evidence for the proposed beneficial effects of genetic testing for smoking-related diseases on smoking cessation, but does suggest the presence of an immediate motivational effect, such that genetic testing resulted in higher risk perception and more motivation to quit smoking.