@article {Schroederii30, author = {Megan J Schroeder and Allison C Hoffman}, title = {Electronic cigarettes and nicotine clinical pharmacology}, volume = {23}, number = {suppl 2}, pages = {ii30--ii35}, year = {2014}, doi = {10.1136/tobaccocontrol-2013-051469}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objective To review the available literature evaluating electronic cigarette (e-cigarette) nicotine clinical pharmacology in order to understand the potential impact of e-cigarettes on individual users, nicotine dependence and public health. Methods Literature searches were conducted between 1 October 2012 and 30 September 2013 using key terms in five electronic databases. Studies were included in the review if they were in English and publicly available; non-clinical studies, conference abstracts and studies exclusively measuring nicotine content in e-cigarette cartridges were excluded from the review. Results Nicotine yields from automated smoking machines suggest that e-cigarettes deliver less nicotine per puff than traditional cigarettes, and clinical studies indicate that e-cigarettes deliver only modest nicotine concentrations to the inexperienced e-cigarette user. However, current e-cigarette smokers are able to achieve systemic nicotine and/or cotinine concentrations similar to those produced from traditional cigarettes. Therefore, user experience is critically important for nicotine exposure, and may contribute to the products{\textquoteright} ability to support and maintain nicotine dependence. Conclusions Knowledge about e-cigarette nicotine pharmacology remains limited. Because a user{\textquoteright}s e-cigarette experience may significantly impact nicotine delivery, future nicotine pharmacokinetic and pharmacodynamic studies should be conducted in experienced users to accurately assess the products{\textquoteright} impact on public health.}, issn = {0964-4563}, URL = {https://tobaccocontrol.bmj.com/content/23/suppl_2/ii30}, eprint = {https://tobaccocontrol.bmj.com/content/23/suppl_2/ii30.full.pdf}, journal = {Tobacco Control} }