RT Journal Article SR Electronic T1 Do electronic cigarettes increase cigarette smoking in UK adolescents? Evidence from a 12-month prospective study JF Tobacco Control JO Tob Control FD BMJ Publishing Group Ltd SP 365 OP 372 DO 10.1136/tobaccocontrol-2016-053539 VO 27 IS 4 A1 Mark Conner A1 Sarah Grogan A1 Ruth Simms-Ellis A1 Keira Flett A1 Bianca Sykes-Muskett A1 Lisa Cowap A1 Rebecca Lawton A1 Christopher J Armitage A1 David Meads A1 Carole Torgerson A1 Robert West A1 Kamran Siddiqi YR 2018 UL http://tobaccocontrol.bmj.com/content/27/4/365.abstract AB Background In cross-sectional surveys, increasing numbers of adolescents report using both electronic cigarettes (e-cigarettes) and cigarettes. This study assessed whether adolescent e-cigarette use was associated prospectively with initiation or escalation of cigarette use.Methods Data were from 2836 adolescents (aged 13–14 years at baseline) in 20 schools in England. At baseline, breath carbon monoxide levels, self-reported e-cigarette and cigarette use, sex, age, friends and family smoking, beliefs about cigarette use and percentage receiving free school meals (measure of socioeconomic status) were assessed. At 12-month follow-up, self-reported cigarette use was assessed and validated by breath carbon monoxide levels.Results At baseline, 34.2% of adolescents reported ever using e-cigarettes (16.0% used only e-cigarettes). Baseline ever use of e-cigarettes was strongly associated with subsequent initiation (n=1726; OR 5.38, 95% CI 4.02 to 7.22; controlling for covariates, OR 4.06, 95% CI 2.94 to 5.60) and escalation (n=318; OR 1.91, 95% CI 1.14 to 3.21; controlling for covariates, this effect became non-significant, OR 1.39, 95% CI 0.97 to 1.82) of cigarette use.Conclusions This is the first study to report prospective relationships between ever use of e-cigarettes and initiation and escalation of cigarette use among UK adolescents. Ever use of e-cigarettes was robustly associated with initiation but more modestly related to escalation of cigarette use. Further research with longer follow-up in a broader age range of adolescents is required.