RT Journal Article SR Electronic T1 Examining the relationship of vaping to smoking initiation among US youth and young adults: a reality check JF Tobacco Control JO Tob Control FD BMJ Publishing Group Ltd SP 629 OP 635 DO 10.1136/tobaccocontrol-2018-054446 VO 28 IS 6 A1 David T Levy A1 Kenneth E Warner A1 K Michael Cummings A1 David Hammond A1 Charlene Kuo A1 Geoffrey T Fong A1 James F Thrasher A1 Maciej Lukasz Goniewicz A1 Ron Borland YR 2019 UL http://tobaccocontrol.bmj.com/content/28/6/629.abstract AB Background The 2018 National Academies of Sciences, Engineering, and Medicine Report found substantial evidence that electronic cigarette use (vaping) by youth is strongly associated with an increased risk of ever using cigarettes (smoking) and moderately associated with progressing to more established smoking. However, the Report also noted that recent increases in vaping have been associated with declining rates of youth smoking. This paper examines the temporal relationship between vaping and youth smoking using multiple data sets to explore the question of whether vaping promotes smoking initiation in the USA.Methods Using publicly available, nationally representative data on smoking and vaping among youth and young adults, we conducted a trend line analysis of deviations from long-term trends in smoking starting from when vaping became more prevalent.Results There was a substantial increase in youth vaping prevalence beginning in about 2014. Time trend analyses showed that the decline in past 30-day smoking prevalence accelerated by two to four times after 2014. Indicators of more established smoking rates, including the proportion of daily smokers among past 30-day smokers, also decreased more rapidly as vaping became more prevalent.Conclusions The inverse relationship between vaping and smoking was robust across different data sets for both youth and young adults and for current and more established smoking. While trying electronic cigarettes may causally increase smoking among some youth, the aggregate effect at the population level appears to be negligible given the reduction in smoking initiation during the period of vaping’s ascendance.