TY - JOUR T1 - PhenX: Agent measures for tobacco regulatory research JF - Tobacco Control JO - Tob Control SP - s20 LP - s26 DO - 10.1136/tobaccocontrol-2019-054976 VL - 29 IS - Suppl 1 AU - Richard O'Connor AU - Clifford H Watson AU - Gary E Swan AU - Destiney S Nettles AU - Rebecca C Geisler AU - Tabitha P Hendershot A2 - , Y1 - 2020/01/01 UR - http://tobaccocontrol.bmj.com/content/29/Suppl_1/s20.abstract N2 - The current paper describes the PhenX (Phenotypes and eXposures) Toolkit Tobacco Regulatory Research Agent specialty area and the Agent Working Group’s (WG’s) 6-month consensus process to identify high-priority, scientifically supported measures for cross-study comparison and analysis. Eleven measures were selected for inclusion in the Toolkit. Eight of these are interviewer-administered or self-administered protocols: history of switching to lower tar and nicotine cigarettes, passive exposures to tobacco products, tobacco brand and variety (covering cigars, cigarettes and smokeless tobacco separately), tobacco product adulteration (vent-blocking or filter-blocking) and tobacco warning label exposure and recall. The remaining three protocols are either laboratory-based or visual inspection-based: measurement of nicotine content in smoked or smokeless tobacco products and the physical properties of these two classes of products. Supplemental protocols include a biomarker of exposure and smoking topography. The WG identified the lack of standard measurement protocols to assess subjective ratings of tobacco product flavours and their appeal to consumers as a major gap. As the characteristics of tobacco products that influence perception and use are tobacco regulatory research priorities, the reliable assessment of flavours remains an area requiring further development. ER -