RT Journal Article
SR Electronic
T1 Emerging ENDS products and challenges in tobacco control toxicity research
JF Tobacco Control
JO Tob Control
FD BMJ Publishing Group Ltd
SP tobaccocontrol-2022-057268
DO 10.1136/tobaccocontrol-2022-057268
A1 Robert M Strongin
A1 Eva Sharma
A1 Hanno C Erythropel
A1 Ahmad El-Hellani
A1 Nada O F Kassem
A1 Vladimir B Mikheev
A1 Alexandra Noël
A1 David H Peyton
A1 Matthew L Springer
YR 2022
UL http://tobaccocontrol.bmj.com/content/early/2022/06/16/tobaccocontrol-2022-057268.abstract
AB Electronic nicotine delivery systems (ENDS) continue to rapidly evolve. Current products pose unique challenges and opportunities for researchers and regulators. This commentary aims to highlight research gaps, particularly in toxicity research, and provide guidance on priority research questions for the tobacco regulatory community. Disposable flavoured ENDS have become the most popular device class among youth and may contain higher nicotine levels than JUUL devices. They also exhibit enhanced harmful and potentially harmful constituents production, contain elevated levels of synthetic coolants and pose environmental concerns. Synthetic nicotine and flavour capsules are innovations that have recently enabled the circumvention of Food and Drug Administration oversight. Coil-less ENDS offer the promise of delivering fewer toxicants due to the absence of heating coils, but initial studies show that these products exhibit similar toxicological profiles compared with JUULs. Each of these topic areas requires further research to understand and mitigate their impact on human health, especially their risks to young users.