TY - JOUR T1 - Assessing toxicant emissions from e-liquids with DIY additives used in response to a potential flavour ban in e-cigarettes JF - Tobacco Control JO - Tob Control SP - s245 LP - s248 DO - 10.1136/tc-2022-057505 VL - 31 IS - Suppl 3 AU - Ahmad El-Hellani AU - Eric K Soule AU - Mohammad Daoud AU - Rola Salman AU - Rachel El Hage AU - Ola Ardati AU - Malak El-Kaassamani AU - Amira Yassine AU - Nareg Karaoghlanian AU - Soha Talih AU - Najat Saliba AU - Alan Shihadeh Y1 - 2022/11/01 UR - http://tobaccocontrol.bmj.com/content/31/Suppl_3/s245.abstract N2 - Significance Electronic cigarettes (e-cigarettes) aerosolise liquids that contain nicotine, propylene glycol, glycerol and appealing flavours. In the USA, regulations have limited the availability of flavoured e-cigarettes in pod-based systems, and further tightening is expected. In response, some e-cigarette users may attempt to make their e-liquids (do-it-yourself, DIY). This study examined toxicant emissions from several aerosolised DIY e-liquids.Methods DIY additives were identified by reviewing users’ responses to a hypothetical flavour ban, e-cigarette internet forums and DIY mixing internet websites. They include essential oils, cannabidiol, sucralose and ethyl maltol. E-liquids with varying concentrations and combinations of additives and tobacco and menthol flavours were prepared and were used to assess reactive oxygen species (ROS), carbonyl and phenol emissions in machine-generated aerosols.Results Data showed that adding DIY additives to unflavoured, menthol-flavoured or tobacco-flavoured e-liquids increases toxicant emissions to levels comparable with those from commercial flavoured e-liquids. Varying additive concentrations in e-liquids did not have a consistently significant effect on the tested emissions, yet increasing power yielded significantly higher ROS, carbonyl and phenol emissions for the same additive concentration. Adding nicotine to DIY e-liquids with sucralose yielded increase in some emissions and decrease in others, with freebase nicotine-containing e-liquid giving higher ROS emissions than that with nicotine salt.Conclusion This study showed that DIY additives can impact aerosol toxicant emissions from e-cigarettes and should be considered by policymakers when restricting commercially available flavoured e-liquids.Data related to the concept mapping and carbonyl and phenol emissions are available upon request. ER -