TY - JOUR T1 - JUUL releases more nicotine in the first puffs JF - Tobacco Control JO - Tob Control SP - 267 LP - 268 DO - 10.1136/tobaccocontrol-2021-056683 VL - 32 IS - 2 AU - Rola Salman AU - Soha Talih AU - Ebrahim Karam AU - Nareg Karaoghlanian AU - David L Ashley AU - Alan Shihadeh Y1 - 2023/03/01 UR - http://tobaccocontrol.bmj.com/content/32/2/267.abstract N2 - Analytical studies that estimate nicotine and other toxicant emissions from electronic cigarettes (e-cigarettes) typically employ a puffing machine to generate 10 or 15 puffs in rapid succession (eg, 30 s between puffs) for subsequent assays.1 2 Such puffing patterns model combustible cigarette use in which every hour or so a smoker takes a 5 min break to consume a cigarette, a use duration intrinsic to the burning rate and length of the cigarette rod. A single cigarette is the default ‘serving size’ to which the consumer commits once the cigarette has been lit. On the contrary, e-cigarettes such as JUUL have no intrinsic serving size; the design is agnostic to a user drawing a single puff or tens of puffs in a use bout. Indeed, emerging evidence suggests that JUUL use patterns are characterised by sporadic puffing throughout the day, for example, at the work desk, during exercise and during class.3 4 … ER -