Results of statistical analyses for all compliance and main outcome measures
| Condition | Day | Condition by day | ||||
|---|---|---|---|---|---|---|
| F Value | p Value | F Value | p Value | F Value | p Value | |
| *df=8,88 | ||||||
| †df=4,44 | ||||||
| ‡df=2,16 | ||||||
| Compliance measures | ||||||
| Expired air CO* | 37.1 | <0.01 | 9.4 | <0.01 | 14.0 | <0.01 |
| Semi-quantitative cotinine† | 45.5 | <0.01 | 27.6 | <0.01 | 27.7 | <0.01 |
| Main outcome measures | ||||||
| Subjective withdrawal* | ||||||
| Urges to smoke | 2.3 | NS | <1.0 | NS | 1.6 | NS |
| Irritability/frustration/anger | 3.2 | NS | 1.3 | NS | 2.7 | <0.05 |
| Anxious | 6.1 | <0.01 | <1.0 | NS | 1.5 | NS |
| Difficulty concentrating | 6.2 | <0.01 | 1.8 | NS | <1.0 | NS |
| Restlessness | 2.7 | NS | <1.0 | NS | 1.7 | NS |
| Hunger | 4.1 | <0.05 | <1.0 | NS | 1.7 | NS |
| Impatient | 6.9 | <0.01 | 1.7 | NS | 1.0 | NS |
| CRAVING a cigarette/nicotine | 3.7 | NS | 1.4 | NS | 1.5 | NS |
| Insomnia/disturbed sleep | <1.0 | NS | <1.0 | NS | 1.4 | NS |
| Increased eating | 9.5 | <0.01 | 4.2 | <0.01 | 3.7 | <0.01 |
| Drowsiness | 2.0 | NS | 3.2 | <0.05 | 1.3 | NS |
| Depression/feeling blue | 5.9 | <0.01 | 1.5 | NS | 1.1 | NS |
| Desire for sweets | 4.5 | <0.05 | 2.1 | NS | 4.2 | <0.01 |
| QSU factor 1 | 6.4 | <0.05 | 1.0 | NS | <1.0 | NS |
| QSU factor 2 | 9.8 | <0.01 | 1.6 | NS | 3.5 | <0.01 |
| Physiological measures* | ||||||
| Heart rate | 15.0 | <0.001 | 2.8 | <0.05 | 3.6 | <0.01 |
| Skin temperature | <1.0 | NS | <1.0 | NS | <1.0 | NS |
| Quantitative cotinine (GC/MS)† | 15.9 | <0.001 | 3.4 | NS | 21.1 | <0.001 |
| NNAL (LC-MS/MS)† | 11.5 | <0.001 | 6.2 | <0.05 | 3.7 | <0.05 |
| Puff topography‡ | ||||||
| Puff volume | 2.9 | NS | <1.0 | NS | <1.0 | NS |
| Puff duration | 1.9 | NS | 1.1 | NS | <1.0 | NS |
| Interpuff interval | 2.5 | NS | 1.0 | NS | <1.0 | NS |
| Number of puffs | 8.5 | <0.05 | <1.0 | NS | 2.1 | NS |