Variables used in the analysis
| Variable | Base case (range for sensitivity analysis) |
|---|---|
| 95% confidence intervals used for sensitivity analysis range for treatment odds ratios. | |
| *Odds ratio for continued cessation after one year, as compared to no intervention. | |
| **Incremental odds ratio for continued cessation after one year, as compared to counselling only. | |
| †Sources: Silagy,6 Silagy et al,7 Fiore MC et al.8 | |
| Natural cessation rate among all smokers (%) | 2.5 (1–4) |
| OR†* counselling only | 1.73 (1.46–2.03) |
| OR†** nicotine gum | 1.66 (1.52–1.82) |
| OR†** nicotine patch | 1.80 (1.61–2.01) |
| OR†** nicotine spray | 2.35 (1.63–3.38) |
| OR†** nicotine inhaler | 2.14 (1.44–3.18) |
| OR†** bupropion | 2.51 (1.5–3.0) |
| Smokers who stop treatment after first month (%) | 50 (40–60) |
| Smokers who stop treatment after second month (%) | 20 (15–25) |
| Lifetime probability of relapse after one year of abstinence (%) | 35 (10–50) |
| Time required for counselling (minutes) | 10 (5–15) |
| Additional physician time required for treatment (minutes) | 90 (75–105) |
| Cost of pharmacological treatments | US prices (12.5–100%) |
| Cost per hour of physicians’ time for counselling (US$) | 11.11 (1.40–22.22) |
| Discount rate (%) | 3 (0–10) |