Neutral red and sister chromatid exchange (SCE) assay of whole smoke from Eclipse prototypes, 1R4F, and 1R5F*
| Cigarette | Neutral red assay (EC50 value) | SCE assay |
|---|---|---|
| *Neutral red values: concentration of mainstream smoke (cigarettes per cubic meter of air) to cause 50% reduction in growth of cell population. A higher concentration of smoke condensate being required to reduce the cell population by 50% is indicative of lower cytoxicity. | ||
| SCE values: slope value, a measure of the increase in the number of sister chromatid exchanges per unit of smoke concentration (cigarettes per cubic meter of air). A lower slope value is indicative of lower mutagenic potential. | ||
| Source: Eclipse Expert Panel.6 | ||
| 1R4F | 5.9 | 0.31 |
| 1R5F | 30.3 | 0.06 |
| GTC 4-098 | 31.4 | 0.06 |
| GTC 5-014 | 34.7 | 0.05 |
| GTC 5-535 | 13.8 | 0.09 |
| GTC 7-026 | 21.7 | 0.06 |