Table 1

Concentrations of bupropion and active metabolites in breast milk, plasma, urine, and saliva

Breast milkPlasmaUrineSaliva
*ng/ml.
Mean (SD) bupropion*45.2 (49.5)25.0 (24.6)1042.0 (2139.0)68.5 (131.4)
    Range4.2–168.32.9–84.532.7–7056.43.2–439.0
Mean (SD) hydroxybupropion104.6 (62.2)940.2 (697.7)2026.4 (1873.0)184.5 (143.9)
    Range9.0–242.164.8–2672.8125.7–5032.825.1–522.3
Mean (SD) erythrohydrobupropion72.1(38.3)84.1 (46.1)2396.2 (1857.0)202.9 (131.1)
    Range25.4–142.919.9–196.5370.1–5972.171.7–491.6
Mean (SD) threohydrobupropion459.0 (278.4 )370.2 (182.9 )18791.3 (16227.0 )1229.5 (794.1 )
    Range192.7–1052.1121.4–746.62484.5–45625.7469.3–3089.1