Mean milk concentration (ng/ml) | Mean milk* concentration (nM/ml) | Infant dose† (μg/kg/day) | Infant dose (nM/kg/day) | Infant dose‡ (% maternal bupropion dose) | |
---|---|---|---|---|---|
*Molecular weights: bupropion 240; hydroxybupropion 256; erythrohydrobupropion and threohydrobupropion 242. | |||||
†Infant dose based on breast milk concentration and infant consumption of 0.15 l/kg/day. | |||||
‡Maternal bupropion dose based on 300 mg/day = 5 mg/kg/day = 20833 nM/kg/day. | |||||
Metabolite percentages based on bupropion molar equivalents. | |||||
Bupropion | 45 | 0.19 | 6.75 | 28.1 | 0.13 |
Hydroxybupropion | 105 | 0.41 | 15.75 | 61.5 | 0.30 |
Erythrohydrobupropion | 72 | 0.30 | 10.8 | 44.6 | 0.21 |
Threohydrobupropion | 459 | 1.90 | 68.85 | 284.5 | 1.37 |
Total | − | − | − | 418.7 | 2.01 |