Table 2

Infant dose of bupropion and metabolites

Mean milk concentration (ng/ml)Mean milk* concentration (nM/ml)Infant dose† (μg/kg/day)Infant dose (nM/kg/day)Infant dose‡ (% maternal bupropion dose)
*Molecular weights: bupropion 240; hydroxybupropion 256; erythrohydrobupropion and threohydrobupropion 242.
†Infant dose based on breast milk concentration and infant consumption of 0.15 l/kg/day.
Maternal bupropion dose based on 300 mg/day  =  5 mg/kg/day  =  20833 nM/kg/day.
Metabolite percentages based on bupropion molar equivalents.
Bupropion450.196.7528.10.13
Hydroxybupropion1050.4115.7561.50.30
Erythrohydrobupropion720.3010.844.60.21
Threohydrobupropion4591.9068.85284.51.37
Total418.72.01