Table 1

 21 day smoke inhalation studies on rats: high concentrations

Project numberSmoke type μg/l TPM†Mortality% initial body weightRectal temperature °C‡Respiratory frequency‡Nasal reserve cell hyperplasiaNasal squamous metaplasiaNasal epithelial cornificationAtrophy olfactory epitheliumNecrosis nasal epitheliumTrachea reserve cell hyperplasia
−, not observed; +, observed; ±, observed in 10% or fewer of subjects; empty cell: no data.
*½: indicates half day exposure (210 minutes instead of 420 minutes).
†1 μg/l: 1000 μg/m3.
‡Body temperature and respiratory frequency were measured at the end of the exposure.
MS, mainstream smoke; SS, sidestream smoke.
304714Sham0150%37107
MS 1701/20 (5%)130%3691+±±
SS 16023/40 (57%)80%3286+++++
306120,22–24Sham0137%36.7113
MS 37117/20 (85%)97%29.698+++++
MS 1810117%34.2111+++
MS 860127%36.8123
SS 890114%33.789+++++
SS 89 ½*0126%34.995+++++
306925–29Sham0140%37107
MS 51016/20 (80%)78%28.395
SS 1192/24 (8%)89%32.774
SS 680114%34.782
308130–33Sham0130%36.3137
MS 52614/24 (58%)82%31.196
MS 2610116%35.9110
SS 13311/24 (46%)86%33.279
SS 590116%36.097
311334Sham0142%
MS 600134%++++
SS 600124%+++++