21 day smoke inhalation studies: low concentrations
| Project number | Exposure type | Smoke type μg/l PM | Nasal reserve cell hyperplasia | Nasal squamous metaplasia | Upper vocal cord hyperplasia | Larynx ventral depression thick | Trachea reserve cell hyperplasia |
|---|---|---|---|---|---|---|---|
| −, not observed; +, observed; ±, observed in 10% or fewer of subjects; empty cell: no data. | |||||||
| *½: indicates half day exposure (210 minutes instead of 420 minutes). | |||||||
| 311467,68 | Head only | Sham | − | − | + | − | ± |
| SS 17 | + | + | + | + | + | ||
| SS 17 ½* | + | + | + | − | + | ||
| SS 5 | + | − | + | − | + | ||
| SS 5 ½* | + | − | + | − | + | ||
| SS 2 | − | − | − | − | + | ||
| SS 2 ½* | − | − | − | − | − | ||
| 312569 | Nose only | Sham | − | − | − | − | − |
| SS 6 | − | − | + | + | + | ||
| SS 2 | − | − | − | + | − | ||
| 312334,71–73 | Whole body | Sham | − | − | − | − | − |
| SS 19 | + | − | − | − | ± | ||
| SS 60 | + | + | − | + | ± | ||