Secondary analyses using multivariate* comparisons of change in desire to smoke from baseline between all products
| Product comparison | Mean difference (95% CI) | Adjusted p value |
| 0 versus 16 mg ENDD | 0.80 (−0.27 to 1.86) | 0.21 |
| 0 mg ENDD versus Nicorette inhalator | 0.69 (−0.38 to 1.77) | 0.33 |
| 0 mg ENDD versus usual cigarette | 2.23 (1.17 to 3.30) | <0.0001 |
| 16 mg ENDD versus Nicorette inhalator | −0.10 (−1.16, 0.95) | 0.99 |
| 16 mg ENDD versus usual cigarette | 1.44 (0.39 to 2.48) | 0.003 |
| Nicorette inhalator versus usual cigarette | 1.54 (0.48 to 2.59) | 0.001 |
ENDD, electronic nicotine delivery device.
↵* Adjusted for treatment period, baseline craving, within-participant correlation as a random effect and multiple comparisons using Tukey-Kramer method.