Gender-specific age-adjusted and cohort-adjusted HRs according to smoking status
| All | Age 40-64 | Age 65–79 | ||||||||
| Never smoked | Former smoker | Current smoker | Never smoked | Former smoker | Current smoker | Never smoked | Former smoker | Current smoker | ||
| Male | ||||||||||
| No at risk | 28720 | 35079 | 76227 | 24407 | 26808 | 65717 | 4313 | 8271 | 10510 | |
| Person-years | 278921 | 328883 | 717199 | 240875 | 258583 | 629061 | 38045 | 70299 | 88137 | |
| Total cardiovascular disease | No of cases | 698 | 1225 | 2383 | 1245 | 423 | 276 | 1138 | 802 | 422 |
| Adjusted HR | 1.00 | 1.18 (1.08,1.30) | 1.51 (1.38,1.64) | 1.00 | 1.26 (1.08,1.46) | 1.77 (1.55,2.02) | 1.00 | 1.13 (1.00,1.27) | 1.33 (1.19,1.49) | |
| Coronary heart disease | No of cases | 118 | 298 | 590 | 337 | 114 | 54 | 253 | 184 | 64 |
| Adjusted HR | 1.00 | 1.73 (1.40,2.14) | 2.19 (1.79,2.67) | 1.00 | 1.78 (1.28,2.46) | 2.50 (1.88,3.34) | 1.00 | 1.68 (1.26,2.24) | 1.92 (1.46,2.53) | |
| All stroke | No of cases | 338 | 506 | 943 | 481 | 159 | 135 | 462 | 347 | 203 |
| Adjusted HR | 1.00 | 1.00 (0.87,1.15) | 1.24 (1.10,1.41) | 1.00 | 0.97 (0.77,1.22) | 1.41 (1.16,1.71) | 1.00 | 1.02 (0.85,1.21) | 1.13 (0.95,1.33) | |
| Intraparenchymal haemorrhage | No of cases | 92 | 117 | 271 | 189 | 54 | 57 | 82 | 63 | 35 |
| Adjusted HR | 1.00 | 0.94 (0.71,1.23) | 1.27 (1.00,1.62) | 1.00 | 0.83 (0.57,1.21) | 1.35 (1.00,1.82) | 1.00 | 1.05 (0.70,1.60) | 1.14 (0.76,1.69) | |
| Subarachnoid haemorrhage | No of cases | 23 | 36 | 132 | 98 | 24 | 18 | 34 | 12 | 5 |
| Adjusted HR | 1.00 | 1.23 (0.73,2.01) | 2.39 (1.53,3.73) | 1.00 | 1.22 (0.66,2.24) | 2.17 (1.31,3.59) | 1.00 | 1.38 (0.49,3.92) | 3.25 (1.26,8.33) | |
| Ischaemic stroke | No of cases | 141 | 221 | 360 | 127 | 46 | 37 | 233 | 175 | 104 |
| Adjusted HR | 1.00 | 0.98 (0.79,1.21) | 1.15 (0.94,1.39) | 1.00 | 0.89 (0.58,1.38) | 1.28 (0.89,1.86) | 1.00 | 1.00 (0.79,1.28) | 1.09 (0.86,1.37) | |
| Female | ||||||||||
| No at risk | 140379 | 3714 | 12717 | 115558 | 2679 | 10555 | 24821 | 1035 | 2162 | |
| Person-years | 1379703 | 33517 | 117171 | 1149857 | 25080 | 99003 | 229845 | 8436 | 18168 | |
| Total cardiovascular disease | No of cases | 2402 | 127 | 375 | 758 | 30 | 157 | 1644 | 97 | 218 |
| Adjusted HR | 1.00 | 1.48 (1.23,1.77) | 1.85 (1.65,2.06) | 1.00 | 1.74 (1.21,2.51) | 2.68 (2.25,3.18) | 1.00 | 1.39 (1.13,1.71) | 1.50 (1.30,1.73) | |
| Coronary heart disease | No of cases | 375 | 30 | 86 | 117 | 7 | 38 | 258 | 23 | 48 |
| Adjusted HR | 1.00 | 2.38 (1.63,3.46) | 2.84 (2.24,3.60) | 1.00 | 2.79 (1.30,6.00) | 4.36 (3.01,6.32) | 1.00 | 2.22 (1.44,3.40) | 2.21 (1.62,3.02) | |
| All stroke | No of cases | 1134 | 50 | 160 | 366 | 15 | 77 | 768 | 35 | 83 |
| Adjusted HR | 1.00 | 1.26 (0.95,1.68) | 1.70 (1.44,2.01) | 1.00 | 1.85 (1.10,3.10) | 2.75 (2.15,3.53) | 1.00 | 1.09 (0.77,1.53) | 1.24 (0.99,1.56) | |
| Intraparenchymal haemorrhage | No of cases | 272 | 14 | 41 | 113 | 6 | 24 | 159 | 8 | 17 |
| Adjusted HR | 1.00 | 1.62 (0.94,2.78) | 1.87 (1.34,2.60) | 1.00 | 2.55 (1.12,5.82) | 2.87 (1.84,4.48) | 1.00 | 1.20 (0.59,2.46) | 1.22 (0.73,2.02) | |
| Subarachnoid haemorrhage | No of cases | 231 | 7 | 51 | 126 | 3 | 35 | 105 | 4 | 16 |
| Adjusted HR | 1.00 | 1.10 (0.52,2.34) | 2.93 (2.15,3.98) | 1.00 | 1.14 (0.36,3.58) | 3.70 (2.53,5.41) | 1.00 | 1.04 (0.38,2.83) | 1.98 (1.16,3.38) | |
| Ischaemic stroke | No of cases | 402 | 17 | 48 | 76 | 5 | 11 | 326 | 12 | 37 |
| Adjusted HR | 1.00 | 1.04 (0.64,1.69) | 1.33 (0.99,1.81) | 1.00 | 2.56 (1.03,6.36) | 1.77 (0.93,3.45) | 1.00 | 0.83 (0.47,1.48) | 1.24 (0.88,1.75) | |
Adjusted HR, HR adjusted by age and cohort.