Table 4

Gender-specific adjusted HRs and 95% CIs of mortality from total cardiovascular disease, coronary heart disease and stroke, according to the number of years since quitting smoking

	Current smoker	Former smoker					Never smoker
	Current smoker	<2 years	2–4 years	5–9 years	10–14 years	15 years and more	Never smoker
Male
No at risk	35079	2170	5745	8040	6442	9455	28720
Person-years	328883	19908	53248	75367	60946	89482	278921
Total cardiovascular disease
No of cases	2383	80	230	281	178	288	698
Adjusted HR	1.00	1.01 (0.81,1.26)	1.00 (0.87,1.15)	0.87 (0.77,0.99)	0.69 (0.59,0.80)	0.53 (0.47,0.60)	0.66 (0.61,0.72)
Multivariable HR*	1.00	1.01 (0.81,1.26)	1.00 (0.87,1.14)	0.88 (0.78,0.99)	0.71 (0.61,0.83)	0.56,0.48,0.65)	0.44 (0.35,0.56)
Multivariable HR†	1.00	1.00 (0.81,1.26)	0.99 (0.87,1.14)	0.87 (0.77,0.99)	0.68 (0.59,0.80)	0.53 (0.46,0.59)	0.52 (0.43,0.62)
Coronary heart disease
No of cases	590	14	61	83	40	60	118
Adjusted HR	1.00	0.73 (0.43,1.23)	1.10 (0.84,1.43)	1.06 (0.84,1.33)	0.63 (0.46,0.87)	0.47 (0.36,0.61)	0.45 (0.37,0.55)
Multivariable HR*	1.00	0.73 (0.43,1.23)	1.10 (0.84,1.43)	1.07 (0.85,1.35)	0.65 (0.47,0.91)	0.51 (0.36,0.70)	0.36 (0.22,0.60)
Multivariable HR†	1.00	0.71 (0.42,1.20)	1.06 (0.81,1.38)	1.02 (0.81,1.29)	0.61 (0.45,0.85)	0.46 (0.35,0.60)	0.36 (0.24,0.52)
Stroke
No of cases	943	34	89	116	67	132	338
Adjusted HR	1.00	1.08 (0.77,1.52)	0.97 (0.78,1.20)	0.90 (0.74,1.10)	0.65 (0.50,0.83)	0.61 (0.51,0.73)	0.80 (0.71,0.91)
Multivariable HR*	1.00	1.09 (0.78,1.54)	0.97 (0.78,1.21)	0.92 (0.76,1.12)	0.68 (0.53,0.87)	0.67 (0.53,0.87)	0.49 (0.35,0.68)
Multivariable HR†	1.00	1.09 (0.78,1.54)	0.97 (0.78,1.21)	0.91 (0.75,1.11)	0.65 (0.50,0.83)	0.60 (0.50,0.72)	0.63 (0.48,0.83)

Female
No at risk	3714	281	686	784	599	810	140379
Person-years	33517	2571	6072	7020	5432	7334	1379703

Total cardiovascular disease
No of cases	375	9	27	27	14	26	2402
Adjusted HR	1.00	0.93 (0.43,1.80)	1.24 (0.84,1.84)	0.79 (0.54,1.17)	0.61 (0.36,1.04)	0.61 (0.41,0.90)	0.54 (0.49,0.61)
Multivariable HR*	1.00	0.90 (0.46,1.75)	1.23 (0.83,1.82)	0.78 (0.53,1.57)	0.60 (0.35,1.02)	0.60 (0.39,0.91)	0.40 (0.25,0.62)
Multivariable HR†	1.00	0.94 (0.48,1.81)	1.21 (0.82,1.79)	0.80 (0.54,1.18)	0.61 (0.36,1.05)	0.63 (0.42,0.93)	0.61 (0.41,0.90)
Coronary heart disease
No of cases	86	4	11	7	2	2	375
Adjusted HR	1.00	1.79 (0.66,4.89)	2.21 (1.18,4.15)	0.92 (0.43,1.98)	0.38 (0.09,1.55)	0.21 (0.05,0.85)	0.35 (0.28,0.45)
Multivariable HR*	1.00	1.74 (0.64,4.77)	2.20 (1.17,4.13)	0.92 (0.42,2.00)	0.38 (0.09,1.56)	0.22 (0.05,0.91)	0.27 (0.10,0.72)
Multivariable HR†	1.00	1.76 (0.65,4.80)	2.14 (1.14,4.02)	0.92 (0.43,1.99)	0.38 (0.09,1.55)	0.21 (0.05,0.87)	0.63 (0.22,1.77)
Stroke
No of cases	160	3	7	11	5	12	1134
Adjusted HR	1.00	0.73 (0.23,2.28)	0.75 (0.35,1.61)	0.77 (0.42,1.41)	0.51 (0.21,1.25)	0.67 (0.37,1.20)	0.59 (0.50,0.70)
Multivariable HR*	1.00	0.68 (0.22,2.12)	0.72 (0.34,1.54)	0.72 (0.39,1.32)	0.47 (0.19,1.14)	0.57 (0.31,1.06)	0.31 (0.17,0.57)
Multivariable HR†	1.00	0.73 (0.23,2.28)	0.73 (0.34,1.56)	0.77 (0.42,1.42)	0.52 (0.21,1.26)	0.69 (0.38,1.24)	0.69 (0.38,1.25)

Adjusted HR, HR adjusted by age and cohort.
↵* Multivariable HR, HR adjusted further by the number of years smoked (category).
↵† Multivariable HR, HR adjusted further by average number of cigarette smoked per day (category).