Comparison of nicotine plasma concentrations, cardiovascular effects, and rating of drug strength between snuff products tested (mean ( SEM))
| Parameter | Mint “snuff” | Copenhagen | Skoal Long Cut Cherry | Skoal Original Wintergreen | Skoal Bandits |
| Plasma nicotine concentration | |||||
| Maximal increase (ng/ml)1-165 | 0.9 (0.4) | 19.5 (4.1)ab | 14.9 (3.0)ab | 14.9 (2.4)ab | 4.2 (1.4) |
| AUC(0–30) (ng/ml min−1)1-165 | 119.4 (43.6) | 530.4 (120.8)abcd | 333.9 (60.7)a | 376.3 (61.6)ab | 208.0 (33.0) |
| Heart rate | |||||
| Maximal increase (bpm)1-165 | 5.1 (1.5) | 16.1 (3.3)ab | 17.9 (3.3)ab | 14.7 (2.7)ab | 4.7 (1.3) |
| AUC(0–30) (bpm min−1)1-165 | 1951.7 (75.1) | 2351.8 (91.3)a | 2280.7 (80.8) | 2221.1 (70.8) | 2028.2 (56.7) |
| Systolic blood pressure | |||||
| Maximal increase (mm Hg) | 8.6 (2.3) | 16.8 (3.0) | 15.9 (2.4) | 14.9 (2.8) | 9.4 (2.0) |
| AUC(0–30) (mm Hg min−1)1-165 | 3341.0 (100.3) | 3688.2 (88.0)abcd | 3537.7 (105.2)a | 3551.7 (58.5)a | 3486.2 (76.4)a |
| Diastolic blood pressure | |||||
| Maximal increase (mm Hg) | 12.5 (3.2) | 14.2 (1.6) | 13.4 (3.0) | 14.0 (2.1) | 10.3 (1.8) |
| AUC(0–30) (mm Hg min−1)1-165 | 2010.8 (80.7) | 2263.0 (56.1)abd | 2129.2 (69.4)a | 2191.1 (56.0)ab | 2036.8 (70.0) |
| Product strength | |||||
| Maximum score (mm)1-165 | 38.0 (9.3) | 81.4 (3.3)abd | 60.6 (4.1)ab | 65.4 (7.8)ab | 34.4 (4.1) |
| AUC(0–30)(mm/min)1-165 | 755.6 (186.9) | 1917.6 (95.5)abcd | 1394.3 (77.9)ab | 1487.6 (188.7)ab | 750.6 (105.6) |
Results of the repeated measures analyses of variance:
1-150 p<0.05;
1-160 p<0.01;
↵1-165 p<.001. Where there were significant differences on the analyses of variance, Tukey's honestly significant difference test was performed to assess differences between products. Superscripted letters indicate significantly higher scores relative to: (a) non-tobacco “mint” snuff; (b) Skoal Bandits; (c) Skoal Original Wintergreen; (d) Skoal Long Cut Cherry; and (e) Copenhagen.