Estimated percentage of adults with nicotine dependence in NESARC excluded from typical clinical trials of treatments for nicotine dependence by traditional efficacy eligibility criteria
| Exclusion variable | Current nicotine dependence (n=4962) % (95% CI) | Motivated to quit smoking sample (n=4121) % (95% CI) |
| Traditional efficacy exclusion criteria* | ||
| 1. Pregnancy | 3.19 (2.67 to 3.80) | 3.46 (2.89 to 4.13) |
| 2. Cardiovascular disorder | 6.84 (5.99 to 7.80) | 6.66 (5.77 to 7.68) |
| 3. Smoking fewer than 10 cigarettes per day on average | 32.02 (29.98 to 34.14) | 33.79 (31.79 to 35.85) |
| 4. Currently/past 6 months take any psychotropic medication | NA | NA |
| 5. High alcohol consumption/alcohol abuse | 13.55 (12.27 to 14.82) | 12.96 (11.73 to 14.30) |
| 6. Not motivated to quit | 17.60 (16.18 to 19.11)_ | 0.00 |
| 7. Use/abuse of other drugs | 3.40 (2.83 to 4.07) | 3.24 (2.64 to 3.98) |
| 8. Having current depression | 16.62 (15.41 to 17.92) | 15.71 (14.41 to 17.10) |
| 9. Currently/past 6 months take bupropion and/or NRT | NA | NA |
| 10. Eating disorder | NA | NA |
| 11. History of psychosis | 2.14 (1.72 to 2.67) | 1.95 (1.52 to 2.51) |
| 12. History of bipolar disorder | 10.33 (9.13 to 11.66) | 9.81 (8.59 to 11.18) |
| Exclusion by any criterion | 65.89 (64.13 to 67.60) | 58.60 (56.57 to 60.61) |
Percentages are weighted values.
↵* Derived from the review of 54 randomised controlled clinical trials (method described in the paper).
NA, information not available in NESARC.