Nicotine exposure in inexperienced e-cigarette users
Reference | Study characteristics | Results | |||||
---|---|---|---|---|---|---|---|
Study product | Labelled nicotine content | Sample size | Use duration | Biomarkers of exposure | Relevant comparisons | Other physiological measures | |
Bullen et al17 | Ruyan V8 | 16 mg | 8 | e-cigarette: 5 min; inhaler: 10 min; cigarette: 5 min | plasma nicotine (venous): Cmax 1.3 ng/mL, Tmax 19.6 min | Nicorette inhaler (10 mg nicotine): Cmax 2.1 ng/mL, Tmax 32 min; own brand cigarette: Cmax 13.4 ng/mL; Tmax 14.3 min | |
Eissenberg19 | NJOY or Crown 7 | 16 mg | 16 | 2 bouts of 10 puffs, 30 s interpuff interval, 1 hr between bouts | plasma nicotine: after 5 min, 2.5 ng/mL (NJOY), 3.5 ng/mL (Crown 7) | own brand cigarette: 16.8 ng/mL | no increases in HR |
Vansickel et al20 | NJOY or Crown 7 | 18 mg, 16 mg | 32 | 2 bouts of 10 puffs, 30 s interpuff interval, 1 h between bouts | no significant changes to plasma nicotine | own brand cigarette: within 5 min, 2.1–18.8 ng/mL | no increases in HR |
Vansickel et al21 | Vapor King | 18 mg/mL | 20 | 6 bouts of 10 puffs, 20 s interpuff interval, 30 min between bouts | plasma nicotine: 5 min after final bout, 2.2–7.4 ng/mL | 5 min after first bout, HR increased from 67.5 to 75 bpm | |
Flouris et al22 | Giant | 11 mg/mL | 15 | Equivalent puffs to approximate nicotine delivery with two own brand cigarettes, based on 1.5 cigarette/e-cigarette nicotine absorption ratio | serum cotinine: significant increases immediately following and 1 h after use | 2 own brand cigarettes: no difference between e-cigarette and cigarette use |
HR, heart rate; bpm, beats per minute; Cmax, maximum drug concentration; Tmax, time at which maximum drug concentration is observed.