Infertility and ORs (95% CIs) of associations with lifetime SHS exposure among 44 560 never-smoking women
| Never-smokers exposed to SHS | Infertility | |||
|---|---|---|---|---|
| No N (%) | Yes N (%) | Crude OR (95% CI) | Adjusted OR (95% CI)* | |
| No SHS exposure | 3577 (9.4) | 573 (8.7) | 1.0 (Ref) | 1.0 (Ref) |
| Any | ||||
| Childhood only | 2240 (5.9) | 357 (5.4) | 0.99 (0.86 to 1.15) | 0.99 (0.86 to 1.16) |
| Adult home only | 2439 (6.4) | 398 (6.0) | 1.02 (0.89 to 1.17) | 1.05 (0.91 to 1.22) |
| Adult work only | 4806 (12.7) | 798 (12.1) | 1.04 (0.92 to 1.16) | 1.00 (0.88 to 1.13) |
| Childhood + adult home | 4120 (10.9) | 660 (10.0) | 1.00 (0.89 to 1.13) | 1.04 (0.91 to 1.18) |
| Childhood + adult work | 3914 (10.3) | 713 (10.8) | 1.14 (1.01 to 1.28) | 1.11 (0.98 to 1.26) |
| Adult home + work | 5124 (13.5) | 895 (13.5) | 1.09 (0.97 to 1.22) | 1.08 (0.96 to 1.22) |
| Childhood + adult home + work | 11 725 (30.9) | 2221 (33.6) | 1.18 (1.07 to 1.31) | 1.17 (1.05 to 1.30) |
| Quantified SHS exposure | ||||
| No childhood + any adult | 12 271 (32.6) | 2074 (31.6) | 1.06 (0.95 to 1.17) | 1.04 (0.94 to 1.16) |
| Childhood <10 years + any adult | 3429 (9.1) | 583 (8.9) | 1.06 (0.94 to 1.20) | 1.08 (0.94 to 1.23) |
| Childhood ≥10 years + adult home <20 years + adult work <10 years | 8695 (23.1) | 1592 (24.2) | 1.14 (1.03 to 1.27) | 1.13 (1.01 to 1.27) |
| Childhood ≥10 years + adult home <20 years + adult work ≥10 years | 3727 (9.9) | 687 (10.5) | 1.15 (1.02 to 1.30) | 1.13 (0.99 to 1.29) |
| Childhood ≥10 years + adult home ≥20 years + adult work <10 years | 3106 (8.3) | 515 (7.8) | 1.04 (0.91 to 1.18) | 1.04 (0.90 to 1.19) |
| Childhood ≥10 years + adult home ≥20 years + adult work ≥10 years | 2833 (7.5) | 544 (8.3) | 1.20 (1.06 to 1.36) | 1.18 (1.02 to 1.35) |
| Missing | 47 | |||
| p trend | 0.005 | 0.013 | ||
*Adjusted for age decades, race, education, alcohol use, insecticide exposure, OC use, BMI at 18 years and hard exercise at 18 years (n=38 767).
BMI, body mass index; OC, oral contraceptive; SHS, secondhand smoke.