Table 5

Earlier age at menopause (<50 years) and ORs (95% CIs) of associations with lifetime SHS exposure among 39 805 never-smoking women

Never-smokers exposed to SHSEarlier age at menopause
<50, n (%)≥50, n (%)Crude OR (95% CI)Adjusted OR (95% CI)*
No SHS exposure1499 (8.7)2211 (9.8)1.0 (Ref)1.0 (Ref)
Any
 Childhood only1029 (6.0)1317 (5.8)1.15 (1.04 to 1.28)1.13 (1.01 to 1.26)
 Adult home only1043 (6.1)1464 (6.5)1.05 (0.95 to 1.16)1.02 (0.91 to 1.14)
 Adult work only2079 (12.1)2960 (13.1)1.04 (0.95 to 1.13)1.03 (0.94 to 1.13)
 Childhood + adult home1837 (10.7)2449 (10.8)1.11 (1.01 to 1.21)1.07 (0.97 to 1.18)
 Childhood + adult work1838 (10.7)2300 (10.2)1.18 (1.08 to 1.29)1.12 (1.01 to 1.23)
 Adult Home + work2364 (13.8)3032 (13.4)1.15 (1.06 to 1.25)1.09 (0.99 to 1.19)
 Childhood + adult home + work5468 (31.9)6915 (30.5)1.17 (1.08 to 1.26)1.09 (1.01 to 1.19)
Quantified SHS exposure
 No childhood + any adult5440 (32.0)7406 (32.9)1.08 (1.01 to 1.17)1.05 (0.97 to 1.14)
 Childhood <10 years + any adult1567 (9.2)2022 (9.0)1.14 (1.04 to 1.25)1.06 (0.96 to 1.18)
 Childhood ≥10 years + adult home <20 years + adult work <10 years4012 (23.6)5290 (23.5)1.12 (1.04 to 1.21)1.07 (0.98 to 1.16)
 Childhood ≥10 years + adult home <20 years + adult work ≥10 years1741 (10.2)2159 (9.6)1.19 (1.09 to 1.30)1.13 (1.03 to 1.25)
 Childhood ≥10 years + adult home ≥20 years + adult work <10 years1419 (8.3)1799 (8.0)1.16 (1.06 to 1.28)1.13 (1.02 to 1.26)
 Childhood ≥10 years + adult home ≥20 years + adult work ≥10 years1337 (7.9)1600 (7.1)1.23 (1.12 to 1.36)1.17 (1.05 to 1.30)
 Missing142
 p trend<0.001<0.001
  • *Adjusted for age decades, race, education, alcohol use, insecticide exposure, OC use, BMI at 18 years, hard exercise at 18 years, and age at menarche (n=34 812).

  • BMI, body mass index; OC, oral contraceptive; SHS, secondhand smoke.